Search for a susceptibility locus to tardive dyskinesia

Toshiya Inada; Izumi Dobashi; Tetsuyoshi Sugita; Ataru Inagaki; Yoshie Kitao; Genichi Matsuda; Shingo Kato; Toshiya Takano; Gohei Yagi; Masahiro Asai

doi:10.1002/(sici)1099-1077(199701/02)12:1<35::aid-hup828>3.0.co;2-%23

Search for a susceptibility locus to tardive dyskinesia

Toshiya Inada, Izumi Dobashi, Tetsuyoshi Sugita, Ataru Inagaki, Yoshie Kitao, Genichi Matsuda, Shingo Kato, Toshiya Takano, Gohei Yagi, Masahiro Asai

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

In order to find a genetic marker for vulnerability to tardive dyskinesia (TD), we looked for an association between vulnerability to TD and polymorphic sites in the gene loci encoding the dopamine D2 receptor (Nco I site), the dopamine D3 receptor (Bal I site), and the dopamine transporter (40-bp, tandem repeat polymorphism). No significant difference was observed in the allele and genotype frequencies of any of the polymorphic sites examined, when comparing psychiatric patients who were specifically vulnerable to TD (n = 49) and those who were not (n = 56). These results suggest that the polymorphic gene loci examined in the present study are unlikely to be of major aetiologic importance in the development of TD.

Original language	English
Pages (from-to)	35-39
Number of pages	5
Journal	Human Psychopharmacology
Volume	12
Issue number	1
DOIs	https://doi.org/10.1002/(sici)1099-1077(199701/02)12:1<35::aid-hup828>3.0.co;2-%23
Publication status	Published - 1997
Externally published	Yes

Keywords

DRD2
DRD3
dopamine transporter
gene
polymorphism
tardive dyskinesia

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/(sici)1099-1077(199701/02)12:1<35::aid-hup828>3.0.co;2-%23

Cite this

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title = "Search for a susceptibility locus to tardive dyskinesia",

abstract = "In order to find a genetic marker for vulnerability to tardive dyskinesia (TD), we looked for an association between vulnerability to TD and polymorphic sites in the gene loci encoding the dopamine D2 receptor (Nco I site), the dopamine D3 receptor (Bal I site), and the dopamine transporter (40-bp, tandem repeat polymorphism). No significant difference was observed in the allele and genotype frequencies of any of the polymorphic sites examined, when comparing psychiatric patients who were specifically vulnerable to TD (n = 49) and those who were not (n = 56). These results suggest that the polymorphic gene loci examined in the present study are unlikely to be of major aetiologic importance in the development of TD.",

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T1 - Search for a susceptibility locus to tardive dyskinesia

AU - Inada, Toshiya

AU - Dobashi, Izumi

AU - Sugita, Tetsuyoshi

AU - Inagaki, Ataru

AU - Kitao, Yoshie

AU - Matsuda, Genichi

AU - Kato, Shingo

AU - Takano, Toshiya

AU - Yagi, Gohei

AU - Asai, Masahiro

PY - 1997

Y1 - 1997

N2 - In order to find a genetic marker for vulnerability to tardive dyskinesia (TD), we looked for an association between vulnerability to TD and polymorphic sites in the gene loci encoding the dopamine D2 receptor (Nco I site), the dopamine D3 receptor (Bal I site), and the dopamine transporter (40-bp, tandem repeat polymorphism). No significant difference was observed in the allele and genotype frequencies of any of the polymorphic sites examined, when comparing psychiatric patients who were specifically vulnerable to TD (n = 49) and those who were not (n = 56). These results suggest that the polymorphic gene loci examined in the present study are unlikely to be of major aetiologic importance in the development of TD.

AB - In order to find a genetic marker for vulnerability to tardive dyskinesia (TD), we looked for an association between vulnerability to TD and polymorphic sites in the gene loci encoding the dopamine D2 receptor (Nco I site), the dopamine D3 receptor (Bal I site), and the dopamine transporter (40-bp, tandem repeat polymorphism). No significant difference was observed in the allele and genotype frequencies of any of the polymorphic sites examined, when comparing psychiatric patients who were specifically vulnerable to TD (n = 49) and those who were not (n = 56). These results suggest that the polymorphic gene loci examined in the present study are unlikely to be of major aetiologic importance in the development of TD.

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KW - DRD3

KW - dopamine transporter

KW - gene

KW - polymorphism

KW - tardive dyskinesia

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Search for a susceptibility locus to tardive dyskinesia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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