Selective inhibition of gastrulation in the starfish embryo by albuside B, an inosine analogue

Takahiko Shimizu, Keiichi Hamada, Haruhiko Isomura, Yuki Myotoishi, Susumu Ikegami, Hiroyuki Kaneko, Marina Dan-Sohkawa

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


External application of 0.2-100 μg/ml albuside B inhibits gastrulation of the starfish (Asterina pectinifera) embryo. Treated embryos retain the late blastula morphology with the vegetal plate. However, the vegetal plate is unreactive to soybean agglutinin, a probe for observing the progenitor cells of the archenteron (mesendoderm) in a normal embryo. The effective period of the treatment is limited from 4 to 6 h after fertilization, a period immediately before the onset of blastulation. RNA synthesis is unaffected during the period of sensitivity. The selectivity of the inhibition shows that albuside B may be a useful tool for studying the mechanisms of mesendoderm differentiation.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalFEBS Letters
Issue number2-3
Publication statusPublished - 1995 Aug 7
Externally publishedYes


  • Albuside B
  • Asterina pectinifera
  • Gastrula
  • Mesendoderm
  • Soybean agglutinin

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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