Septal deafferentation enhances the neurotrophic effects of rat hippocampus on cultured neural cells from the central nervous system

Kazunari Yoshida; Shinichi Kohsaka; Takeshi Idei; Seiji Nii; Mitsuhiro Otani; Shigeo Toya; Yasuzo Tsukada

doi:10.1016/0304-3940(86)90187-4

Septal deafferentation enhances the neurotrophic effects of rat hippocampus on cultured neural cells from the central nervous system

Kazunari Yoshida, Shinichi Kohsaka, Takeshi Idei, Seiji Nii, Mitsuhiro Otani, Shigeo Toya, Yasuzo Tsukada

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Neurotrophic effects (NTEs) of various brain regions of 4-week-old rats were examined in primary culture of rat embryonic cerebral hemispheres. Extracts of the hippocampus, brainstem and septal nucleus highly enhanced the survivability of neuronal cells and the division of non-neuronal cells by 9 days. The septohippocampal tract (fimbria fornix) was cut and the effect on the neurotrophic activity in the hippocampus was examined. The NTEs of hippocampal extracts remained unchanged 3 days after septal deafferentation, was significantly increased by 7 days, peaked at 14 days and returned to the basal level by 21 days.

Original language	English
Pages (from-to)	181-186
Number of pages	6
Journal	Neuroscience Letters
Volume	66
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(86)90187-4
Publication status	Published - 1986 May 15
Externally published	Yes

Keywords

deafferentation
hippocampus
neurotrophic factor
rat
tissue culture

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(86)90187-4

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title = "Septal deafferentation enhances the neurotrophic effects of rat hippocampus on cultured neural cells from the central nervous system",

abstract = "Neurotrophic effects (NTEs) of various brain regions of 4-week-old rats were examined in primary culture of rat embryonic cerebral hemispheres. Extracts of the hippocampus, brainstem and septal nucleus highly enhanced the survivability of neuronal cells and the division of non-neuronal cells by 9 days. The septohippocampal tract (fimbria fornix) was cut and the effect on the neurotrophic activity in the hippocampus was examined. The NTEs of hippocampal extracts remained unchanged 3 days after septal deafferentation, was significantly increased by 7 days, peaked at 14 days and returned to the basal level by 21 days.",

keywords = "deafferentation, hippocampus, neurotrophic factor, rat, tissue culture",

author = "Kazunari Yoshida and Shinichi Kohsaka and Takeshi Idei and Seiji Nii and Mitsuhiro Otani and Shigeo Toya and Yasuzo Tsukada",

note = "Funding Information: The authorsa reg ratefutlo Dr. S. Hirano and Dr. H. Asou, Departmenotf Physiology, Toho UniversityS chool of Medicine,f or useful discussiona nd to Miss Y. Kamishikiryof or technicaal ssistanceT.h e presents tudywas supportedb y grants from the Ministry of Education,S ciencea nd Culture and from the Japan Brain Foundation.",

year = "1986",

month = may,

day = "15",

doi = "10.1016/0304-3940(86)90187-4",

language = "English",

volume = "66",

pages = "181--186",

journal = "Neuroscience Letters",

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T1 - Septal deafferentation enhances the neurotrophic effects of rat hippocampus on cultured neural cells from the central nervous system

AU - Yoshida, Kazunari

AU - Kohsaka, Shinichi

AU - Idei, Takeshi

AU - Nii, Seiji

AU - Otani, Mitsuhiro

AU - Toya, Shigeo

AU - Tsukada, Yasuzo

N1 - Funding Information: The authorsa reg ratefutlo Dr. S. Hirano and Dr. H. Asou, Departmenotf Physiology, Toho UniversityS chool of Medicine,f or useful discussiona nd to Miss Y. Kamishikiryof or technicaal ssistanceT.h e presents tudywas supportedb y grants from the Ministry of Education,S ciencea nd Culture and from the Japan Brain Foundation.

PY - 1986/5/15

Y1 - 1986/5/15

N2 - Neurotrophic effects (NTEs) of various brain regions of 4-week-old rats were examined in primary culture of rat embryonic cerebral hemispheres. Extracts of the hippocampus, brainstem and septal nucleus highly enhanced the survivability of neuronal cells and the division of non-neuronal cells by 9 days. The septohippocampal tract (fimbria fornix) was cut and the effect on the neurotrophic activity in the hippocampus was examined. The NTEs of hippocampal extracts remained unchanged 3 days after septal deafferentation, was significantly increased by 7 days, peaked at 14 days and returned to the basal level by 21 days.

AB - Neurotrophic effects (NTEs) of various brain regions of 4-week-old rats were examined in primary culture of rat embryonic cerebral hemispheres. Extracts of the hippocampus, brainstem and septal nucleus highly enhanced the survivability of neuronal cells and the division of non-neuronal cells by 9 days. The septohippocampal tract (fimbria fornix) was cut and the effect on the neurotrophic activity in the hippocampus was examined. The NTEs of hippocampal extracts remained unchanged 3 days after septal deafferentation, was significantly increased by 7 days, peaked at 14 days and returned to the basal level by 21 days.

KW - deafferentation

KW - hippocampus

KW - neurotrophic factor

KW - rat

KW - tissue culture

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ER -

Septal deafferentation enhances the neurotrophic effects of rat hippocampus on cultured neural cells from the central nervous system

Abstract

Keywords

ASJC Scopus subject areas

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