Serotonin 2A receptor gene polymorphism and personality traits: No evidence for significant association

Mamoru Tochigi, Tadashi Umekage, Chieko Kato, Tetsuya Marui, Takeshi Otowa, Hiroyuki Hibino, Toshiyuki Otani, Kazuhisa Kohda, Nobumasa Kato, Tsukasa Sasaki

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


A number of studies have observed associations between the serotonin 2A (5-HT2A) receptor and mental disorders. Here, we investigated correlations between polymorphisms (-1438G/A and 102T/C) of the 5-HT 2A gene and personality traits in healthy Japanese volunteers (n = 239). The personality traits were evaluated using the Revised NEO Personality Inventory (NEO PI-R). The -1438G/A and 102T/C were in complete linkage disequilibrium. There was a tendency for associations between the genotype and the scores for Agreeableness, Conscientiousness and Neuroticism of the NEO PI-R (P=0.028, 0.039 and 0.062, respectively; analysis of variance, uncorrected for multiple testing). Subjects with the A/A of -1438G/A (or T/T of 102T/C) appeared to be lower in Neuroticism and higher in Conscientiousness than the rest of the subjects. However, the results were statistically non-significant after Bonferroni's correction for multiple testing of the five scales of the NEO PI-R. Thus, the present study provided no evidence for statistically significant associations between the 5-HT2A polymorphisms and the personality traits.

Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalPsychiatric Genetics
Issue number1
Publication statusPublished - 2005 Mar
Externally publishedYes


  • Harm avoidance
  • NEO PI-R
  • Personality trait
  • Polymorphism
  • STAI
  • Serotonin 2A receptor

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Psychiatry and Mental health
  • Biological Psychiatry


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