Serum antioxidants and age-related macular degeneration among older Japanese

Takehiro Michikawa, Susumu Ishida, Yuji Nishiwaki, Yuriko Kikuchi, Tazuru Tsuboi, Kanae Hosoda, Ai Ishigami, Satoko Iwasawa, Makiko Nakano, Toru Takebayashi

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


From the perspective of human nutrition, the prevention of age-related macular degeneration (AMD) through diet control is feasible and desirable. We investigated the relationship between serum antioxidants and AMD in the community-dwelling older Japanese eating a typical Japanese diet. In this study, 722 subjects aged 65 years or older (297 males and 425 females) who had gradable fundus photographs were included. The subjects were divided into three groups of early or late AMD or non-maculopathy. Serum antioxidants (alpha-, gammatocopherols, retinol, beta-cryptoxanthin, alpha-, beta-carotenes, lycopene, and lutein and zeaxanthin) were measured with high-performance liquid chromatography. To clarify the combined effect as the group of the antioxidants, we defined the carotene family (alpha-, beta-carotenes and lycopene) and carotenoid family (betacryptoxanthin, alpha-, beta-carotenes, lycopene, lutein and zeaxanthin). Tertiles of each serum antioxidant were obtained and the prevalence of early or late AMD was compared with univariate or multivariate analysis. The overall prevalence of early AMD was 4.4% (95% confidence interval: 3.1-6.2) and late AMD was 1.1% (0.5-2.2). Only alpha-tocopherol and beta-cryptoxanthin were related to late AMD as single antioxidants. On the other hand, the carotene and carotenoid families as a combination of antioxidants were protectively associated with late AMD. No relationship was found between serum antioxidants and early AMD. Our findings support the hypothesis that a combination of serum antioxidants obtained from the traditional Japanese diet is protective for late AMD, but not for early AMD.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalAsia Pacific journal of clinical nutrition
Issue number1
Publication statusPublished - 2009 Mar 1


  • Age-related macular degeneration (AMD)
  • Aged
  • Diet
  • Japan
  • Serum antioxidants

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


Dive into the research topics of 'Serum antioxidants and age-related macular degeneration among older Japanese'. Together they form a unique fingerprint.

Cite this