Serum interleukin-18 levels are elevated in schizophrenia

Kenji F. Tanaka; Futoshi Shintani; Yasuo Fujii; Gohei Yagi; Masahiro Asai

doi:10.1016/S0165-1781(00)00196-7

Serum interleukin-18 levels are elevated in schizophrenia

Kenji F. Tanaka, Futoshi Shintani, Yasuo Fujii, Gohei Yagi, Masahiro Asai

Division of Brain Sciences

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

Interleukin-18 (IL-18) is a recently discovered proinflammatory cytokine which plays a pivotal role in T helper 1 (Th1) responses. IL-18 is produced by macrophage-like cells, and inappropriate IL-18 production has been known to be involved in immunological disturbances. Schizophrenia is a common disease whose pathogenesis is still unclear; however, an activation of the inflammatory response system, including the Th1 cytokine response, may be related to the pathophysiology of schizophrenia. We measured the serum IL-18 levels of 66 schizophrenics and age- and sex-matched control subjects by using an ELISA assay. We found significantly increased serum IL-18 levels in the schizophrenic patients (P = 0.0002). This finding supports the hypothesis that immune activation is involved in the pathophysiology of schizophrenia. (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	75-80
Number of pages	6
Journal	Psychiatry Research
Volume	96
Issue number	1
DOIs	https://doi.org/10.1016/S0165-1781(00)00196-7
Publication status	Published - 2000 Sept 25

Keywords

Cytokines
Immune activation
Immunology
Interleukin-18
Schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-1781(00)00196-7

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title = "Serum interleukin-18 levels are elevated in schizophrenia",

abstract = "Interleukin-18 (IL-18) is a recently discovered proinflammatory cytokine which plays a pivotal role in T helper 1 (Th1) responses. IL-18 is produced by macrophage-like cells, and inappropriate IL-18 production has been known to be involved in immunological disturbances. Schizophrenia is a common disease whose pathogenesis is still unclear; however, an activation of the inflammatory response system, including the Th1 cytokine response, may be related to the pathophysiology of schizophrenia. We measured the serum IL-18 levels of 66 schizophrenics and age- and sex-matched control subjects by using an ELISA assay. We found significantly increased serum IL-18 levels in the schizophrenic patients (P = 0.0002). This finding supports the hypothesis that immune activation is involved in the pathophysiology of schizophrenia. (C) 2000 Elsevier Science Ireland Ltd.",

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author = "Tanaka, {Kenji F.} and Futoshi Shintani and Yasuo Fujii and Gohei Yagi and Masahiro Asai",

note = "Funding Information: We thank Takanori Koizumi, Hiroyuki Shimada, Nobuo Ohtsuka, and Alfons Deeken for their encouragement, Mitsuhiro Kamakura for helpful discussion, and Emiko Fukasawa and Takane Sakuma for excellent technical assistance. K.T. is supported by a Keio University Grant-in-Aid for the Encouragement of Young Medical Scientists. F.S. is supported by a Grant-in-Aid from the Ministry of Education, Science and Culture. G.Y. is supported by an Ohme Keiyu Hospital Research Grant.",

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AU - Tanaka, Kenji F.

AU - Shintani, Futoshi

AU - Fujii, Yasuo

AU - Yagi, Gohei

AU - Asai, Masahiro

N1 - Funding Information: We thank Takanori Koizumi, Hiroyuki Shimada, Nobuo Ohtsuka, and Alfons Deeken for their encouragement, Mitsuhiro Kamakura for helpful discussion, and Emiko Fukasawa and Takane Sakuma for excellent technical assistance. K.T. is supported by a Keio University Grant-in-Aid for the Encouragement of Young Medical Scientists. F.S. is supported by a Grant-in-Aid from the Ministry of Education, Science and Culture. G.Y. is supported by an Ohme Keiyu Hospital Research Grant.

PY - 2000/9/25

Y1 - 2000/9/25

N2 - Interleukin-18 (IL-18) is a recently discovered proinflammatory cytokine which plays a pivotal role in T helper 1 (Th1) responses. IL-18 is produced by macrophage-like cells, and inappropriate IL-18 production has been known to be involved in immunological disturbances. Schizophrenia is a common disease whose pathogenesis is still unclear; however, an activation of the inflammatory response system, including the Th1 cytokine response, may be related to the pathophysiology of schizophrenia. We measured the serum IL-18 levels of 66 schizophrenics and age- and sex-matched control subjects by using an ELISA assay. We found significantly increased serum IL-18 levels in the schizophrenic patients (P = 0.0002). This finding supports the hypothesis that immune activation is involved in the pathophysiology of schizophrenia. (C) 2000 Elsevier Science Ireland Ltd.

AB - Interleukin-18 (IL-18) is a recently discovered proinflammatory cytokine which plays a pivotal role in T helper 1 (Th1) responses. IL-18 is produced by macrophage-like cells, and inappropriate IL-18 production has been known to be involved in immunological disturbances. Schizophrenia is a common disease whose pathogenesis is still unclear; however, an activation of the inflammatory response system, including the Th1 cytokine response, may be related to the pathophysiology of schizophrenia. We measured the serum IL-18 levels of 66 schizophrenics and age- and sex-matched control subjects by using an ELISA assay. We found significantly increased serum IL-18 levels in the schizophrenic patients (P = 0.0002). This finding supports the hypothesis that immune activation is involved in the pathophysiology of schizophrenia. (C) 2000 Elsevier Science Ireland Ltd.

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Serum interleukin-18 levels are elevated in schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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