Serum interleukin-18 levels are elevated in schizophrenia

Kenji F. Tanaka, Futoshi Shintani, Yasuo Fujii, Gohei Yagi, Masahiro Asai

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)


Interleukin-18 (IL-18) is a recently discovered proinflammatory cytokine which plays a pivotal role in T helper 1 (Th1) responses. IL-18 is produced by macrophage-like cells, and inappropriate IL-18 production has been known to be involved in immunological disturbances. Schizophrenia is a common disease whose pathogenesis is still unclear; however, an activation of the inflammatory response system, including the Th1 cytokine response, may be related to the pathophysiology of schizophrenia. We measured the serum IL-18 levels of 66 schizophrenics and age- and sex-matched control subjects by using an ELISA assay. We found significantly increased serum IL-18 levels in the schizophrenic patients (P = 0.0002). This finding supports the hypothesis that immune activation is involved in the pathophysiology of schizophrenia. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalPsychiatry Research
Issue number1
Publication statusPublished - 2000 Sept 25


  • Cytokines
  • Immune activation
  • Immunology
  • Interleukin-18
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'Serum interleukin-18 levels are elevated in schizophrenia'. Together they form a unique fingerprint.

Cite this