TY - JOUR
T1 - Serum leptin and total dietary energy intake
T2 - The INTERLIPID Study
AU - Nakamura, Yasuyuki
AU - Ueshima, Hirotsugu
AU - Okuda, Nagako
AU - Murakami, Yoshitaka
AU - Miura, Katsuyuki
AU - Kita, Yoshikuni
AU - Okamura, Tomonori
AU - Okayama, Akira
AU - Turin, Tanvir C.
AU - Choudhry, Sohel R.
AU - Rodriguez, Beatriz
AU - Curb, J. David
AU - Stamler, Jeremiah
N1 - Funding Information:
Acknowledgments The INTERMAP/INTERLIPID Study has been accomplished through the fine work of staff at local, national, and international centers. A partial listing of colleagues is in the acknowledgement of reference 10. This study was supported in part by a grant-in-aid of the Japanese Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research: (A) 090357003, (C) 17590563, and (C) 19590655 in Japan and the Suntory Company; the Pacific Research Institute is supported by the Robert Perry Fund and the Hawaii Community Foundation. The INTERMAP Hawaii Center was funded by the National Heart, Lung, and Blood Institute, National Institutes of Health (Grant 5-RO1-HL54868-03). The INTERMAP Study is supported by the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, U.S.A. (Grant 2-RO1-HL50490), as well as national and local agencies in the four countries.
PY - 2013/9
Y1 - 2013/9
N2 - Purpose: It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese-Americans in Hawaii and Japanese in Japan. Methods: Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40-59 years from two population samples, one Japanese-American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m2, 25-29.9 kg/m2, and ≥30 kg/m2) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake. Results: In multivariate regression analyses, in those with BMI < 25 kg/m2 and in those with BMI between 25 and 29.9 kg/m2, log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m2, it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m 2 (P < 0.001). Conclusion: Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons.
AB - Purpose: It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese-Americans in Hawaii and Japanese in Japan. Methods: Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40-59 years from two population samples, one Japanese-American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m2, 25-29.9 kg/m2, and ≥30 kg/m2) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake. Results: In multivariate regression analyses, in those with BMI < 25 kg/m2 and in those with BMI between 25 and 29.9 kg/m2, log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m2, it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m 2 (P < 0.001). Conclusion: Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons.
KW - Body mass
KW - Japanese in Japan and Hawaii
KW - Leptin
KW - Obesity
KW - Population study
KW - Total energy intake
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U2 - 10.1007/s00394-012-0469-3
DO - 10.1007/s00394-012-0469-3
M3 - Article
C2 - 23224055
AN - SCOPUS:84891829091
SN - 1436-6207
VL - 52
SP - 1641
EP - 1648
JO - European Journal of Nutrition
JF - European Journal of Nutrition
IS - 6
ER -
