Serum leptin and total dietary energy intake: The INTERLIPID Study

Yasuyuki Nakamura, Hirotsugu Ueshima, Nagako Okuda, Yoshitaka Murakami, Katsuyuki Miura, Yoshikuni Kita, Tomonori Okamura, Akira Okayama, Tanvir C. Turin, Sohel R. Choudhry, Beatriz Rodriguez, J. David Curb, Jeremiah Stamler

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Purpose: It has been hypothesized that leptin-induced appetite suppression is impaired in obese individuals, but little human evidence is available documenting this. We investigated relations between serum leptin and total energy intake using INTERLIPID/INTERMAP data on Japanese-Americans in Hawaii and Japanese in Japan. Methods: Serum leptin and nutrient intakes were examined by standardized methods in men and women aged 40-59 years from two population samples, one Japanese-American in Hawaii (88 men, 94 women), the other Japanese in central Japan (123 men, 111 women). Multiple linear regression analyses stratified by BMI category (<25 kg/m2, 25-29.9 kg/m2, and ≥30 kg/m2) with adjustment for possible confounders were used to examine the relation between log-leptin and total dietary energy intake. Results: In multivariate regression analyses, in those with BMI < 25 kg/m2 and in those with BMI between 25 and 29.9 kg/m2, log-leptin was not significantly related to total dietary energy intake; in those with BMI ≥ 30 kg/m2, it was significantly inversely related to total dietary energy intake (P = 0.029), independent of body weight and physical activity. Physical activity score was significantly positively related to total dietary energy intake only in participants with BMI < 25 kg/m 2 (P < 0.001). Conclusion: Leptin was significantly inversely associated with dietary energy intake in obese persons, but not in overweight and normal-weight persons.

Original languageEnglish
Pages (from-to)1641-1648
Number of pages8
JournalEuropean Journal of Nutrition
Issue number6
Publication statusPublished - 2013 Sept
Externally publishedYes


  • Body mass
  • Japanese in Japan and Hawaii
  • Leptin
  • Obesity
  • Population study
  • Total energy intake

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


Dive into the research topics of 'Serum leptin and total dietary energy intake: The INTERLIPID Study'. Together they form a unique fingerprint.

Cite this