Serum magnesium, ambulatory blood pressure, and carotid artery alteration: The ohasama study

Takanao Hashimoto, Azusa Hara, Takayoshi Ohkubo, Masahiro Kikuya, Yoriko Shintani, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Atsuhiro Kanno, Manami Nakashita, Shiho Terata, Taku Obara, Takuo Hirose, Haruhisa Hoshi, Kazuhito Totsune, Hiroshi Satoh, Yutaka Imai

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Background To investigate the associations of 24-h ambulatory blood pressure (ABP) and serum magnesium level (sMg) with risk of carotid artery alteration in a general population.Methods sMg and ABP, monitored every 30min, were measured in 728 subjects (mean age, 67 years) from the Japanese general population. The extent of carotid artery alteration was evaluated according to mean common carotid intima-media thickness (IMT) and the presence of focal carotid plaque. To determine the association of sMg and carotid artery alteration, analysis of covariance (ANCOVA) (for adjusted mean IMT) or multiple logistic regression analysis (for odds ratio (OR) for the presence of carotid plaques) was used. Results Lower sMg was significantly associated with mean IMT (P = 0.004) and risk of ≥ 2 carotid plaques (P = 0.03) after adjusting for possible confounding factors, including 24-h ABP (systolic), creatinine clearance (Ccr) (estimated using the Cockcroft-Gault equation), and serum minerals (sodium, potassium, calcium, and inorganic phosphorus). Even when 24-h ABP values were within normal range (<130/80mmHg), lower sMg levels (<2.2mg/dl) were significantly associated with mean IMT (P = 0.007) and risk of >2 carotid plaques (OR, 2.14; 95% confidence interval, 1.18-3.85; P = 0.01). Conclusions Both 24-h ABP and lower sMg were closely and independently associated with risk of carotid artery alteration. Further investigations are needed to examine the relationship between sMg levels and the incidence of cardiovascular disease.

Original languageEnglish
Pages (from-to)1292-1298
Number of pages7
JournalAmerican journal of hypertension
Issue number12
Publication statusPublished - 2010 Dec
Externally publishedYes


  • ambulatory blood pressure
  • blood pressure
  • carotid plaque
  • general population
  • hypertension
  • intima-media thickness
  • serum magnesium

ASJC Scopus subject areas

  • Internal Medicine


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