Serum vascular adhesion protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes

Nami Yoshikawa, Kousuke Noda, Hajime Shinoda, Atsuro Uchida, Yoko Ozawa, Kazuo Tsubota, Yukihiko Mashima, Susumu Ishida

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Aims: To study serum levels of soluble vascular adhesion protein (sVAP)-1 in type II diabetic patients with retinopathy. Methods: Serum samples were obtained from 53 consecutive patients, including 14 cases with non-angiogenic ocular diseases, i.e., epiretinal membrane (ERM) and idiopathic macular hole (MH), 19 cases with age-related macular degeneration (AMD), and 20 cases with diabetic retinopathy (DR). Protein levels of sVAP-1, intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, and vascular endothelial growth factor (VEGF) were determined by enzyme-linked immunosorbent assay. Enzymatic activity of semicarbazide-sensitive amine oxidase (SSAO) was also measured. Results: Serum level of sVAP-1 showed a moderate correlation with SSAO activity in all cases. Patients with DR had higher levels of serum sVAP-1 than subjects with ERM and MH, or those with AMD; however, severity of DR is not related to the serum levels of sVAP-1. Serum sVAP-1 correlated positively with VEGF in patients with DR, but not in those with ERM and MH, or those with AMD. Neither soluble ICAM-1 nor VCAM-1 correlated with VEGF, even in subjects with DR. Conclusion: The current data demonstrate the elevated serum levels of sVAP-1 and correlation between sVAP-1 and VEGF in patients with type II diabetes.

Original languageEnglish
Pages (from-to)162-166
Number of pages5
JournalJournal of Diabetes and its Complications
Issue number2
Publication statusPublished - 2013 Mar


  • Diabetic retinopathy
  • Semicarbazide-sensitive amine oxidase
  • Vascular adhesion protein-1
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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