SH2-B is required for both male and female reproduction

Satoshi Ohtsuka, Satoshi Takaki, Masanori Iseki, Kanta Miyoshi, Naomi Nakagata, Yuki Kataoka, Nobuaki Yoshida, Kiyoshi Takatsu, Akihiko Yoshimura

Research output: Contribution to journalArticlepeer-review

58 Citations (Scopus)


Many growth factors and hormones modulate the reproductive status in mammals. Among these, insulin and insulin-like growth factor I (IGF-I) regulate the development of gonadal tissues. SH2-B has been shown to interact with insulin and IGF-I receptors, although the role of SH2-B in these signals has not been clarified. To investigate the role of SH2-B, we generated mice with a targeted disruption of the SH2-B gene. Both male and female SH2-B-/- mice showed slight retardation in growth and impaired fertility. Female knockout mice possess small, anovulatory ovaries with reduced numbers of follicles and male SH2-B-/- mice have small testes with a reduced number of sperm. SH2-B-/-cumulus cells do not respond to either follicle-stimulating hormone or IGF-I. These data suggest that SH2-B plays a critical role in the IGF-I-mediated reproductive pathway in mice.

Original languageEnglish
Pages (from-to)3066-3077
Number of pages12
JournalMolecular and cellular biology
Issue number9
Publication statusPublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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