Shear stress-induced platelet aggregation in various types of von Willebrand disease

Yaeko Nakagawa-Nishimura, Mitsuhiko Sugimoto, Shizuko Tsuji, Mitsuhiro Kuwahara, Kenji Nishio, Yukihiro Takahashi, Yoshihiro Fujimura, Mitsuru Murata, Makoto Handa, Yasuo Ikeda, Akira Yoshioka

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We here examined the shear stress-induced platelet aggregation (SIPA) in various types of von Willebrand Disease (vWD), using a novel cone-and-plate viscometer recently developed by Ikeda et al. [1]. Under experimental conditions of high shear stress (90-108 dyne/cm2) known to induce von Willebrand factor (vWF)-dependent platelet aggregation in normal individuals, a variety of SIPA patterns, from a normal to total defect, were observed in 6 patients with type I vWD, while SIPA was totally absent in all 7 type IIA patients examined. One patient with Normandy type vWD exhibited a normal SIPA pattern under these experimental conditions. These findings, together with the vWF parameters of each patient, suggested that the presence of higher molecular weight multimers of plasma vWF, as well as an appropriate level of vWF antigen, is essential for SIPA to occur under high shear stress. Interestingly, vWF-dependent SIPA in 3 patients with type IIB vWD was found to be initiated by a low shear stress force, which did not induce such platelet aggregation in normal individuals. This might explain the intravessel platelet clumping that occurs, resulting in the intermittent thrombocytopenia observed in this type of the disease.

Original languageEnglish
Pages (from-to)189-196
Number of pages8
JournalInternational journal of hematology
Issue number4
Publication statusPublished - 1995 Jun 1


  • Shear stress-induced platelet aggregation
  • von Willebrand disease
  • von Willebrand factor

ASJC Scopus subject areas

  • Hematology


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