TY - JOUR
T1 - Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions
AU - Kumagai, Naoya
AU - Muncipinto, Giovanni
AU - Schreiber, Stuart L.
PY - 2006/5/26
Y1 - 2006/5/26
N2 - (Chemical Equation Presented) An efficient synthetic pathway to skeletally and stereochemically diverse molecules is described. Densely functionalized amino alcohols were readily synthesized through a Petasis three-component, boronic acid Mannich reaction. Their intramolecular cyclization provided a collection of diverse single-isomer compounds with 15 different types of skeletons in three to five steps.
AB - (Chemical Equation Presented) An efficient synthetic pathway to skeletally and stereochemically diverse molecules is described. Densely functionalized amino alcohols were readily synthesized through a Petasis three-component, boronic acid Mannich reaction. Their intramolecular cyclization provided a collection of diverse single-isomer compounds with 15 different types of skeletons in three to five steps.
KW - Amino alcohols
KW - Diversity-oriented synthesis
KW - Multicomponent reactions
KW - Petasis reaction
KW - Synthesis design
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U2 - 10.1002/anie.200600497
DO - 10.1002/anie.200600497
M3 - Article
C2 - 16646101
AN - SCOPUS:33746272686
SN - 1433-7851
VL - 45
SP - 3635
EP - 3638
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 22
ER -