Significance of biopsy with ERCP for diagnosis of bile duct invasion of DLBCL

Yusuke Ito, Masashi Miyauchi, Tomoka Nakamura, Naminatsu Takahara, Yousuke Nakai, Kazuki Taoka, Kazuhiro Toyama, Aya Shinozaki-Ushiku, Kazuhiko Koike, Mineo Kurokawa

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Obstructive jaundice is an initial symptom in 1–2% of diffuse large B cell lymphoma (DLBCL) cases. The major cause of bile duct obstruction in patients with DLBCL is extrinsic compression by enlarged lymph nodes. In such cases, the existence of bile duct invasion of lymphoma is rarely mentioned or observed pathologically, so the ratio of bile duct invasion to the total cases of obstructive jaundice, and its significance remains unknown. We report two cases of DLBCL presenting as an obstructive jaundice, in which we demonstrated bile duct invasion pathologically by biopsy from the wall of common bile duct with endoscopic retrograde cholangiopancreatography (ERCP). Endoscopic stent placement is a minimally invasive procedure to relieve cholestasis and is effective for diagnosing bile duct invasion. This procedure should thus be performed in all cases of obstructive jaundice caused by lymphoma to evaluate for bile duct invasion. Our cases suggest that ERCP may be useful as a diagnostic procedure for bile duct invasion.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalInternational journal of hematology
Issue number3
Publication statusPublished - 2019 Sept 20
Externally publishedYes


  • Bile duct invasion
  • Diffuse large B cell lymphoma (DLBCL)
  • Endoscopic retrograde cholangiopancreatography (ERCP)

ASJC Scopus subject areas

  • Hematology


Dive into the research topics of 'Significance of biopsy with ERCP for diagnosis of bile duct invasion of DLBCL'. Together they form a unique fingerprint.

Cite this