Significance of int-2/hst-l Coamplification as a Prognostic Factor in Patients with Esophageal Squamous Carcinoma

Yuhkoh Kitagawa, Masakazu Ueda, Nobutoshi Ando, Yohtaro Shinozawa, Nobuyoshi Shimizu, Osahiko Abe

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140 Citations (Scopus)


The correlation between the clinical outcome in patients with esophagealsquamous cell carcinoma and coamplification of the protooncogenesint-2 and h\t-\. which are partially homologous to angiogenesis-inducingfibroblast growth factor, was analyzed retrospectively. Coamplificationof these genes was examined by slot-blot hybridization using DNAsextracted from formalin-fixed and paraffin-embedded blocks of tissues.These tissues were obtained from 107 patients with esophageal squamouscell carcinoma who had undergone radical surgery, int-2/hst-l coamplification greater than 3-fold was observed in the primary tumors of 30 of107 cases (28%), and in the mctastatic lymph nodes of 12 of 40 cases(30%). The cumulative survival rate of patients with int-2/hst-\coamplification in the primary tumors was significantly lower than that of thepatients without coamplification (P < 0.001), and there were no significant differences between the clinicopathological backgrounds of the 2groups, lnt-2 h\t-\ coamplification was also significantly correlated witha high incidence of eventual metastasis in distant organs in these patients.These results suggest that int-2/hsf-\coamplification is a new Biologicalindicator of prognosis and distant organ metastasis in patients withesophageal squamous cell carcinoma.

Original languageEnglish
Pages (from-to)1504-1508
Number of pages5
JournalCancer Research
Issue number5
Publication statusPublished - 1991 Mar

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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