Silver-catalyzed incorporation of carbon dioxide into o-alkynylaniline derivatives

Tomonobu Ishida, Satoshi Kikuchi, Tatsuyuki Tsubo, Tohru Yamada

Research output: Contribution to journalArticlepeer-review

124 Citations (Scopus)


Benzoxazine-2-one derivatives are important heterocycle structures because of their various pharmaceutical activities, though their synthetic methods had been limited. In some cases, toxic reagents, such as phosgene or carbon monoxide, are required. It was found that a silver catalyst successfully promoted the incorporation of CO2 into o-alkynylanilines to afford the corresponding benzoxazine-2-ones bearing Z exo-olefin via 6-exo-dig cyclization at the activated C-C triple bond.

Original languageEnglish
Pages (from-to)848-851
Number of pages4
JournalOrganic Letters
Issue number4
Publication statusPublished - 2013 Feb 15

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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