Small RNA-Mediated Quiescence of Transposable Elements in Animals

Kuniaki Saito; Mikiko C. Siomi

doi:10.1016/j.devcel.2010.10.011

Small RNA-Mediated Quiescence of Transposable Elements in Animals

Kuniaki Saito, Mikiko C. Siomi

Research output: Contribution to journal › Review article › peer-review

132 Citations (Scopus)

Abstract

Transposable elements (TEs) are major components of the intergenic regions of the genome. However, TE transposition has the potential to threaten the reproductive fitness of the organism; therefore, organisms have evolved specialized molecular systems to sense and repress the expression of TEs to stop them from jumping to other genomic loci. Emerging evidence suggests that Argonaute proteins play a critical role in this process, in collaboration with two types of cellular small RNAs: PIWI-interacting RNAs (piRNAs) of the germline and endogenous small interfering RNAs (endo-siRNAs) of the soma, both of which are transcribed from TEs themselves.

Original language	English
Pages (from-to)	687-697
Number of pages	11
Journal	Developmental Cell
Volume	19
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2010.10.011
Publication status	Published - 2010 Nov 16
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

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10.1016/j.devcel.2010.10.011

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title = "Small RNA-Mediated Quiescence of Transposable Elements in Animals",

abstract = "Transposable elements (TEs) are major components of the intergenic regions of the genome. However, TE transposition has the potential to threaten the reproductive fitness of the organism; therefore, organisms have evolved specialized molecular systems to sense and repress the expression of TEs to stop them from jumping to other genomic loci. Emerging evidence suggests that Argonaute proteins play a critical role in this process, in collaboration with two types of cellular small RNAs: PIWI-interacting RNAs (piRNAs) of the germline and endogenous small interfering RNAs (endo-siRNAs) of the soma, both of which are transcribed from TEs themselves.",

author = "Kuniaki Saito and Siomi, {Mikiko C.}",

note = "Funding Information: We thank H. Siomi and other members of the Siomi laboratory for discussions and comments on the manuscript. This work was supported by Ministry of Education, Culture, Sports, Science, and Technology of Japan grants to K.S. and M.C.S. K.S. is supported by Precursory Research for Embryonic Science and Technology from Japan Science and Technology Agency. M.C.S. is supported by Core Research for Evolutional Science and Technology from the Japan Science and Technology Agency.",

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AU - Saito, Kuniaki

AU - Siomi, Mikiko C.

N1 - Funding Information: We thank H. Siomi and other members of the Siomi laboratory for discussions and comments on the manuscript. This work was supported by Ministry of Education, Culture, Sports, Science, and Technology of Japan grants to K.S. and M.C.S. K.S. is supported by Precursory Research for Embryonic Science and Technology from Japan Science and Technology Agency. M.C.S. is supported by Core Research for Evolutional Science and Technology from the Japan Science and Technology Agency.

PY - 2010/11/16

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N2 - Transposable elements (TEs) are major components of the intergenic regions of the genome. However, TE transposition has the potential to threaten the reproductive fitness of the organism; therefore, organisms have evolved specialized molecular systems to sense and repress the expression of TEs to stop them from jumping to other genomic loci. Emerging evidence suggests that Argonaute proteins play a critical role in this process, in collaboration with two types of cellular small RNAs: PIWI-interacting RNAs (piRNAs) of the germline and endogenous small interfering RNAs (endo-siRNAs) of the soma, both of which are transcribed from TEs themselves.

AB - Transposable elements (TEs) are major components of the intergenic regions of the genome. However, TE transposition has the potential to threaten the reproductive fitness of the organism; therefore, organisms have evolved specialized molecular systems to sense and repress the expression of TEs to stop them from jumping to other genomic loci. Emerging evidence suggests that Argonaute proteins play a critical role in this process, in collaboration with two types of cellular small RNAs: PIWI-interacting RNAs (piRNAs) of the germline and endogenous small interfering RNAs (endo-siRNAs) of the soma, both of which are transcribed from TEs themselves.

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Small RNA-Mediated Quiescence of Transposable Elements in Animals

Abstract

ASJC Scopus subject areas

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