SOCS: Negative regulators of cytokine signaling for immune tolerance

Akihiko Yoshimura, Minako Ito, Setsuko Mise-Omata, Makoto Ando

Research output: Contribution to journalReview articlepeer-review

13 Citations (Scopus)


Cytokines are important intercellular communication tools for immunity. Many cytokines promote gene transcription and proliferation through the JAK/STAT (Janus kinase/signal transducers and activators of transcription) and the Ras/ERK (GDP/GTP-binding rat sarcoma protein/extracellular signal-regulated kinase) pathways, and these signaling pathways are tightly regulated. The SOCS (suppressor of cytokine signaling) family members are representative negative regulators of JAK/STAT-mediated cytokine signaling and regulate the differentiation and function of T cells, thus being involved in immune tolerance. Human genetic analysis has shown that SOCS family members are strongly associated with autoimmune diseases, allergy and tumorigenesis. SOCS family proteins also function as immune-checkpoint molecules that contribute to the unresponsiveness of T cells to cytokines.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalInternational immunology
Issue number12
Publication statusPublished - 2021 Dec 1


  • Anergy
  • Autoimmunity
  • JAK kinase
  • Regulatory T cells
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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