SOD1 gene polymorphisms in sudden sensorineural hearing loss

Ryosuke Kitoh, Shin Ya Nishio, Kaoru Ogawa, Makito Okamoto, Ken Kitamura, Kiyofumi Gyo, Hiroaki Sato, Tsutomu Nakashima, Satoshi Fukuda, Kunihiro Fukushima, Akira Hara, Tatsuya Yamasoba, Shin Ichi Usami

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Conclusion The results suggest that SOD1 rs4998557 could be associated with susceptibility to SSNHL in the Japanese population. Objectives To assess the gene association with sudden sensorineural hearing loss (SSNHL). Methods A two-stage case control study was conducted to explore the relationship of the candidate genes to SSNHL. The 192 gene samples from SSNHL patients registered in the intractable inner ear disease gene bank were enrolled. As the candidate genes, 39 SNPs from 31 genes were selected for the first stage study. The second stage study examined whether the SOD1 gene polymorphisms, defined by significant differences between cases and controls in the first stage study, are associated with SSNHL. Results Significant differences were observed in four SNPs from three genes, Glutathione-S-transferase pai 1 (GSTP1), proteine kinase C heta (PRKCH), and superoxide dismutase 1 (SOD1), in terms of allele frequency between SSNHL patients and HapMap controls. In the SOD1 gene, a significant difference was observed in the dominant model study of the SNP rs4998557 in the second stage study. Furthermore, as a result of dividing SSNHL patients based on the clinical data, the difference was more apparent in the case of the over 60 dB group and the tinnitus-positive group.

Original languageEnglish
Pages (from-to)465-469
Number of pages5
JournalActa Oto-Laryngologica
Issue number5
Publication statusPublished - 2016 May 3


  • Allele frequency
  • Candidate gene
  • Clinical data
  • Dominant model
  • Gene bank

ASJC Scopus subject areas

  • Otorhinolaryngology


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