Solid-phase modular synthesis of park nucleotide and lipids i and II analogues

Akira Katsuyama; Kousuke Sato; Fumika Yakushiji; Takanori Matsumaru; Satoshi Ichikawa

doi:10.1248/cpb.c17-00828

Solid-phase modular synthesis of park nucleotide and lipids i and II analogues

Akira Katsuyama
, Kousuke Sato
, Fumika Yakushiji
, Takanori Matsumaru
, Satoshi Ichikawa

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

Abstract

A solid-phase synthesis of Park nucleotide as well as lipids I and II analogues, which is applicable to the synthesis of a range of analogues, is described in this work. This technique allows highly functionalized macromolecules to be modularly labeled. Multiple steps are used in a short time (4 d) with a single purification step to synthesize the molecules by solid-phase synthesis.

Original language	English
Pages (from-to)	84-95
Number of pages	12
Journal	Chemical and Pharmaceutical Bulletin
Volume	66
Issue number	1
DOIs	https://doi.org/10.1248/cpb.c17-00828
Publication status	Published - 2018
Externally published	Yes

Keywords

Natural product
Peptidoglycan
Solid-phase synthesis

ASJC Scopus subject areas

General Chemistry
Drug Discovery

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10.1248/cpb.c17-00828

Cite this

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title = "Solid-phase modular synthesis of park nucleotide and lipids i and II analogues",

abstract = "A solid-phase synthesis of Park nucleotide as well as lipids I and II analogues, which is applicable to the synthesis of a range of analogues, is described in this work. This technique allows highly functionalized macromolecules to be modularly labeled. Multiple steps are used in a short time (4 d) with a single purification step to synthesize the molecules by solid-phase synthesis.",

keywords = "Natural product, Peptidoglycan, Solid-phase synthesis",

author = "Akira Katsuyama and Kousuke Sato and Fumika Yakushiji and Takanori Matsumaru and Satoshi Ichikawa",

note = "Funding Information: Acknowledgments The authors wish to thank Ms. S. Oka (Center for Instrumental Analysis, Hokkaido University) for measurement of the mass spectra. This research was supported by the JSPS Grant-in-Aid for Scientific Research (B) (SI, Grant Number 25293026), The Ministry of Education, Culture, Sports, Science and Technology through the Program for Leading Graduate Schools (Hokkaido University “Ambitious Leader{\textquoteright}s Program”), and the Platform Project for Supporting Drug Discovery and Life Science Research (Platform for Drug Discovery, Informatics and Structural Life Science). Publisher Copyright: {\textcopyright} 2018 The Pharmaceutical Society of Japan.",

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doi = "10.1248/cpb.c17-00828",

language = "English",

volume = "66",

pages = "84--95",

journal = "Chemical and Pharmaceutical Bulletin",

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publisher = "Pharmaceutical Society of Japan",

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T1 - Solid-phase modular synthesis of park nucleotide and lipids i and II analogues

AU - Katsuyama, Akira

AU - Sato, Kousuke

AU - Yakushiji, Fumika

AU - Matsumaru, Takanori

AU - Ichikawa, Satoshi

N1 - Funding Information: Acknowledgments The authors wish to thank Ms. S. Oka (Center for Instrumental Analysis, Hokkaido University) for measurement of the mass spectra. This research was supported by the JSPS Grant-in-Aid for Scientific Research (B) (SI, Grant Number 25293026), The Ministry of Education, Culture, Sports, Science and Technology through the Program for Leading Graduate Schools (Hokkaido University “Ambitious Leader’s Program”), and the Platform Project for Supporting Drug Discovery and Life Science Research (Platform for Drug Discovery, Informatics and Structural Life Science). Publisher Copyright: © 2018 The Pharmaceutical Society of Japan.

PY - 2018

Y1 - 2018

N2 - A solid-phase synthesis of Park nucleotide as well as lipids I and II analogues, which is applicable to the synthesis of a range of analogues, is described in this work. This technique allows highly functionalized macromolecules to be modularly labeled. Multiple steps are used in a short time (4 d) with a single purification step to synthesize the molecules by solid-phase synthesis.

AB - A solid-phase synthesis of Park nucleotide as well as lipids I and II analogues, which is applicable to the synthesis of a range of analogues, is described in this work. This technique allows highly functionalized macromolecules to be modularly labeled. Multiple steps are used in a short time (4 d) with a single purification step to synthesize the molecules by solid-phase synthesis.

KW - Natural product

KW - Peptidoglycan

KW - Solid-phase synthesis

UR - https://www.scopus.com/pages/publications/85039763856

UR - https://www.scopus.com/pages/publications/85039763856#tab=citedBy

U2 - 10.1248/cpb.c17-00828

DO - 10.1248/cpb.c17-00828

M3 - Review article

C2 - 29311516

AN - SCOPUS:85039763856

SN - 0009-2363

VL - 66

SP - 84

EP - 95

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 1

ER -

Solid-phase modular synthesis of park nucleotide and lipids i and II analogues

Abstract

Keywords

ASJC Scopus subject areas

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