Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Masahiro Ogata; K. Oka; Masako Seki; Midori Hoshi; Hirokatsu Takatsu; Tadahiko Mashino; Shiro Urano; Toyoshige Endo

doi:10.1248/bpb.30.1565

Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Masahiro Ogata, K. Oka, Masako Seki, Midori Hoshi, Hirokatsu Takatsu, Tadahiko Mashino, Shiro Urano, Toyoshige Endo

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.

Original language	English
Pages (from-to)	1565-1568
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	30
Issue number	8
DOIs	https://doi.org/10.1248/bpb.30.1565
Publication status	Published - 2007 Aug

Keywords

Ascorbic acid
Dipropofol
Monosaccharide
Solubilization

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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10.1248/bpb.30.1565

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abstract = "Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.",

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author = "Masahiro Ogata and K. Oka and Masako Seki and Midori Hoshi and Hirokatsu Takatsu and Tadahiko Mashino and Shiro Urano and Toyoshige Endo",

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AU - Ogata, Masahiro

AU - Oka, K.

AU - Seki, Masako

AU - Hoshi, Midori

AU - Takatsu, Hirokatsu

AU - Mashino, Tadahiko

AU - Urano, Shiro

AU - Endo, Toyoshige

PY - 2007/8

Y1 - 2007/8

N2 - Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.

AB - Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.

KW - Ascorbic acid

KW - Dipropofol

KW - Monosaccharide

KW - Solubilization

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Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Abstract

Keywords

ASJC Scopus subject areas

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