Sonographic appearance of the submandibular glands in patients with immunoglobulin G4-related disease

Satomi Asai, Kenji Okami, Naoya Nakamura, Shuichi Shiraishi, Tomohiro Yamashita, Damdinsuren Anar, Hiromichi Matsushita, Hayato Miyachi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Swelling of the salivary glands is often an initial sign of immunoglobulin G4 (IgG4)-related disease or IgG4-related sclerosing/autoimmune disease. We encountered 2 patients with IgG4-related disease who showed swollen submandibular glands with a unique characteristic sonographic pattern. Bilateral submandibular glands of both patients were enlarged with a smooth contour. The internal echo texture indicated multiple hypoechoic foci scattered against a heterogeneous background, which characteristically appeared with a mottled or irregular netlike appearance. A histopathologic examination of a resected section showed multiple foci of dense infiltrated lymphoplasmacytic cells and lymph follicles encircled by fibrous bands. A mottled appearance in the sonographic findings of the submandibular glands suggests the characteristic of IgG4-related disease and can be helpful in the differential diagnosis at the initial manifestation.

Original languageEnglish
Pages (from-to)489-493
Number of pages5
JournalJournal of Ultrasound in Medicine
Issue number3
Publication statusPublished - 2012 Mar 1
Externally publishedYes


  • Immunoglobulin G4-related disease
  • Mottled pattern
  • Salivary glands
  • Sonography

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging


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