Spatial Frequency-Based Characterization of Disturbance Rejection in Molecular Communication Systems

Taishi Kotsuka, Yutaka Hori

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


In nature, bacteria regulate their population-level behavior using a molecular communication (MC) mechanism mediated by signaling molecules that diffuse between cells. The MC mechanism has been actively used in recent synthetic biology to transmit the state of genetic circuits, but it is not clear how the cell-cell communication channel affects the performance of the MC systems. In this paper, we propose a computational method to analyze the impact of disturbance on cell-cell MC systems based on a general reaction-diffusion model of MC systems. More specifically, we present an algebraic equation to compute the performance metric of the rejection of disturbance for each spatial frequency. Finally, we illustrate the proposed method by analyzing an activator-repressor-diffuser network and discuss the effect of the diffusive communication on disturbance response.

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalIEEE Transactions on Molecular, Biological, and Multi-Scale Communications
Issue number1
Publication statusPublished - 2022 Mar 1


  • Molecular communication
  • biological control systems
  • control theory
  • robust control

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Modelling and Simulation
  • Computer Networks and Communications
  • Electrical and Electronic Engineering


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