Spin-echo planar spectroscopic imaging for fast lipid characterization in bone marrow

Sumi Bao, Charles R.G. Guttmann, John P. Mugler, James R. Brookeman, Lawrence P. Panych, Robert A. Kraft, Koichi Oshio, Diego Jaramillo, Ferenc A. Jolesz, Daniel S. Williamson, Robert V. Mulkern

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two- dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.

Original languageEnglish
Pages (from-to)1203-1210
Number of pages8
JournalMagnetic Resonance Imaging
Issue number8
Publication statusPublished - 1999 Oct
Externally publishedYes


  • Echo planar imaging (EPI)
  • H MRS
  • Lipids

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging


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