Spirolactam capped cyanine dyes for designing NIR probes to target multiple metal ions

Chirantan Kar, Yutaka Shindo, Kotaro Oka, Shigeru Nishiyama, Koji Suzuki, Daniel Citterio

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


A cyanine based spirocyclic metal ion probe has been reported, which can be tuned easily for targeting various metal ions. The mechanism of selective sensing was verified by designing two novel compounds IR-NCS and IR-PYR, which can selectively sense Hg2+ and Zn2+/Cd2+ ions respectively in a mixed aqueous medium and physiological pH. The spectral changes in both the cases are in the near infrared (NIR) region. Both chemodosimetric and coordination based approaches were used for sensing the cations. The complete mechanism of the sensing events was studied using UV-Vis and fluorescence spectroscopy. Additional insight about the experimental findings was corroborated by theoretical studies using DFT calculations. The confocal microscopic study revealed that the probe IR-NCS can be effectively used for detecting intracellular levels of Hg2+ ions without showing any toxic effect to the model human cells.

Original languageEnglish
Pages (from-to)24970-24980
Number of pages11
JournalRSC Advances
Issue number40
Publication statusPublished - 2017

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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