Split Genes

K. Fujishima, A. Kanai

Research output: Chapter in Book/Report/Conference proceedingChapter


Genomic and transcriptomic analyses have revealed an unexpected complexity of genes in diverse living organisms. In eukaryotes, most protein-coding genes are interrupted by intronic sequences, which split the genes into multiple exons. Most of these genes undergo a process called 'alternative splicing', in which cis-encoded exons are joined in different combinations to produce various messenger RNAs (mRNAs). Some eukaryotic mRNAs and archaeal tRNAs are produced by the trans-splicing of multiple transcripts expressed from distinct genes. In this article, we introduce the different modes of gene splitting found in the Eukaryotes and the Archaea and discuss their possible roles in biological systems.

Original languageEnglish
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages2
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
Publication statusPublished - 2013 Feb 27


  • Alternative splicing
  • Exon
  • Intron
  • RNA-splicing endonuclease
  • Trans-splicing

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry,Genetics and Molecular Biology
  • General Medicine


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