Spontaneous lacrimal punctal occlusion associated with ocular chronic graft-versus-host disease

Mizuka Kamoi, Yoko Ogawa, Murat Dogru, Miki Uchino, Motoko Kawashima, Eiki Goto, Takehiko Mori, Shinichiro Okamoto, Jun Shimazaki, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)


Purpose: To investigate the clinical features of spontaneous lacrimal punctal occlusion (SLPO) after allogeneic hematopoietic stem cell transplantation (HSCT). Methods: One hundred nineteen recipients after HSCT who visited Keio University between 2001 and 2004 were examined. The condition of the lacrimal punctum, severity of dry eye, meibomian gland secretion, and presence of systemic chronic graft-versus-host disease (cGVHD) were determined with or without SLPO by retrospective chart review. Results: Among the 119 recipients, SLPO was diagnosed in 8. All the patients with SLPO after HSCT had meibomian gland dysfunction (MGD), dry eye, and systemic cGVHD. The percentage of patients with dry eye, MGD, and systemic cGVHD were significantly higher in recipients with SLPO than non-SLPO recipients (p < 0.0013, p < 0.00015, p < 0.0008, respectively). Conclusions: SLPO is a clinical presentation of ocular cGVHD and may be an indicator of the severity of dry eye and systemic cGVHD after HSCT.

Original languageEnglish
Pages (from-to)837-842
Number of pages6
JournalCurrent Eye Research
Issue number10
Publication statusPublished - 2007 Oct
Externally publishedYes


  • Chronic graft-versus-host disease
  • Dry eye
  • Hematopoietic stem cell transplantation
  • Meibomian gland dysfunction
  • Spontaneous lacrimal punctal occlusion

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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