Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness

Hiromasa Inoue, Reiko Kato, Satoru Fukuyama, Atsushi Nonami, Kouji Taniguchi, Koichiro Matsumoto, Takako Nakano, Miyuki Tsuda, Mikiko Matsumura, Masato Kubo, Fumihiko Ishikawa, Byoung Gon Moon, Kiyoshi Takatsu, Yoichi Nakanishi, Akihiko Yoshimura

Research output: Contribution to journalArticlepeer-review

105 Citations (Scopus)


T helper 2 cytokines, including interleukin (IL)-4, IL-5, and IL-13, play a critical role in allergic asthma. These cytokines transmit signals through the Janus kinase/signal transducer and activator of transcription (STAT) and the Ras-extracellular signal-regulated kinase (ERK) signaling pathways. Although the suppressor of cytokine signaling (SOCS) family proteins have been shown to regulate the STAT pathway, the mechanism regulating the ERK pathway has not been clarified. The Sprouty-related Ena/VASP homology 1-domain-containing protein (Spred)-1 has recently been identified as a negative regulator of growth factor-mediated, Ras-dependent ERK activation. Here, using Spred-1 -deficient mice, we demonstrated that Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness, without affecting helper T cell differentiation. Biochemical assays indicate that Spred-1 suppresses IL-5-dependent cell proliferation and ERK activation. These data indicate that Spred-1 negatively controls eosinophil numbers and functions by modulating IL-5 signaling in allergic asthma.

Original languageEnglish
Pages (from-to)73-82
Number of pages10
JournalJournal of Experimental Medicine
Issue number1
Publication statusPublished - 2005 Jan 3
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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