SQUID neuromagnetometric reconstruction of brain activity

Manbir Singh, R. Ricardo Brechner, Koichi Oshio, Richard Leahy, Victor W. Henderson

Research output: Contribution to journalConference articlepeer-review


Ionic flow associated with neural activation of the brain produces a magnetic field that can be measured outside the head in a magnetically unshielded room using a highly sensitive neuromagnetometer based on a superconducting quantum interference device (SQUID). Reconstruction of images portraying the tomographic distribution of neural generators (assumed to be current dipoles) of the neuromagnetic field, a modality that we have termed "neuromagnetic imaging" or NMI, represents a powerful noninvasive method of dynamic functional imaging dependent upon brain structure and activity. Reconstruction in NMI, i.e., the inverse problem, however, has no unique solution and requires incorporation of modeling constraints for practical implementation. Results of several phantom and test-object studies and a preliminary human study to develop the method of NMI under various modeling constraints are presented.

Original languageEnglish
Pages (from-to)417-426
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
Publication statusPublished - 2010 Dec 1
Externally publishedYes
EventDigital Image Synthesis and Inverse Optics - San Diego, CA, United States
Duration: 1990 Jul 91990 Jul 13

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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