Stability of amorphous indomethacin compounded with silica

Tomoyuki Watanabe, Naoki Wakiyama, Fusao Usui, Masaru Ikeda, Tetsuhiko Isobe, Mamoru Senna

Research output: Contribution to journalArticlepeer-review

131 Citations (Scopus)


The stability of indomethacin (IM) compounded with SiO2 either by co-grinding or by melt-quenching was examined by recrystallization kinetics under the conditions 30 °C and 11% relative humidity. A decrease of the recrystallization rate with and without an appreciable induction period was observed in both compounds. Higher stability of amorphous IM compounded with SiO2 was attained by prolonged co-grinding than by melt-quenching. This was explained by the stronger chemical interaction at the interface between IM and SiO2 by co-grinding, as revealed by 29Si and 13C solid state NMR. Incomplete co-grinding with the rest of the crystalline state, however, made the amorphous state appreciably unstable, since the remaining crystallites serve as seeds for recrystallization.

Original languageEnglish
Pages (from-to)81-91
Number of pages11
JournalInternational Journal of Pharmaceutics
Issue number1-2
Publication statusPublished - 2001 Sept 11


  • Co-ground mixture
  • Crystallization
  • Indomethacin
  • Interaction
  • Solid-state NMR

ASJC Scopus subject areas

  • Pharmaceutical Science


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