Status of patients who underwent uninephrectomy in adulthood more than 20 years ago

Akira Ohishi, Hiromichi Suzuki, Hidetomo Nakamoto, Hiroshige Katsumata, Kouichi Hayashi, Munekazu Ryuzaki, Kazuhiro Kumagai, Tomohiro Furukawa, Atsuhiro Ichihara, Takao Saruta, Fuyuhiko Higashi, Ken Marumo

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36 Citations (Scopus)


We investigated the status of patients without systemic diseases who had undergone uninephrectomy for unilateral renal diseases in adulthood more than 20 years ago at Tokyo Denryoku Hospital. There were 21 participants (mean age ± SD, 58.6 ± 8.0 years) who fulfilled these criteria. The average interval since nephrectomy was 27.9 ± 6.2 years. The mean current creatinine clearance was 88.5 ± 21.2 mL/min/1.73 m2, which is 92.9% of that in healthy age- and sex-matched controls with two kidneys. The 24-hour urine protein excretion in these patients was only slightly higher than in the controls (214 ± 190 mg v 119 ± 62 mg, P = NS). Age at nephrectomy, length of time with a single kidney, or sex had little effect on the remnant renal functions. There was a positive correlation between current mean arterial pressure and serum creatinine (r = 0.44, P < 0.05). Patients who developed hypertension after uninephrectomy had a family history of hypertension more frequently than those with normotension (86% v 29%, P < 0.05). We conclude that (1) renal function after compensatory hyperfiltration of more than 20 years due to uninephrectomy for unilateral renal diseases in adulthood is well maintained, although hypertension has a considerable effect on the renal functions, and that (2) family history of hypertension plays a key role in determining the incidence of hypertension even in the uninephrectomized patients.

Original languageEnglish
Pages (from-to)889-897
Number of pages9
JournalAmerican Journal of Kidney Diseases
Issue number6
Publication statusPublished - 1995 Dec
Externally publishedYes


  • Uninephrectomy
  • family history of hypertension
  • hypertension
  • remnant renal function
  • unilateral renal disease

ASJC Scopus subject areas

  • Nephrology


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