Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase induction in isolated mouse epidermal cells

Itsumi Kiyoto; Satoshi Yamamoto; Eriko Aizu; Ryuichi Kato

doi:10.1016/0006-291X(87)90938-7

Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase induction in isolated mouse epidermal cells

Itsumi Kiyoto, Satoshi Yamamoto, Eriko Aizu, Ryuichi Kato

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

49 Citations (Scopus)

Abstract

Staurosporine, a most potent protein kinase C inhibitor, actually inhibited protein kinase C activity obtained either from cytosol or particulate fraction of mouse epidermis. Staurosporine at the concentrations which exert protein kinase C inhibition, however, failed to inhibit, but markedly augmented 12-O-tetradecanoylphorbol-13-acetate (TPA)-caused ornithine decarboxylase (ODC) induction in isolated mouse epidermal cells. Staurosporine by itself induced ODC activity as TPA does. Mechanism of ODC induction seems different between these two compounds. Another protein kinase C inhibitor, H-7, inhibited both staurosporine- and TPA-caused ODC induction.

Original language	English
Pages (from-to)	740-746
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	148
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(87)90938-7
Publication status	Published - 1987 Oct 29

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase induction in isolated mouse epidermal cells. / Kiyoto, Itsumi; Yamamoto, Satoshi; Aizu, Eriko et al.
In: Biochemical and Biophysical Research Communications, Vol. 148, No. 2, 29.10.1987, p. 740-746.

Research output: Contribution to journal › Article › peer-review

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Staurosporine, a potent protein kinase C inhibitor, fails to inhibit 12-O-tetradecanoylphorbol-13-acetate-caused ornithine decarboxylase induction in isolated mouse epidermal cells

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