Stem cell theory for the pathogenesis of endometriosis

Tetsuo Maruyama, Yasunori Yoshimura

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Proposed hypothetical causes of endometriosis include retrograde menstruation, lymphatic and vascular metastasis, iatrogenic direct implantation, coelomic metaplasia, embryonic rest, and mesenchymal cell differentiation (induction). Each theory, individually, fails to account for all types of endometriotic lesions, thereby implicating combined and/or type-specific mechanisms. Recent evidence supports the presence of endometrial stem/progenitor cells and their possible involvement in eutopic endometrial regeneration and differentiation. Thus an additional novel mechanism for the origin of endometriotic lesions is that they arise from ectopic endometrial stem/progenitor cells.

Original languageEnglish
Pages (from-to)2754-2763
Number of pages10
JournalFrontiers in Bioscience - Elite
Volume4 E
Issue number8
Publication statusPublished - 2012 Jun 1


  • Bone Marrow
  • Endometriosis
  • Endometrium
  • Endothelial Cells
  • Endothelial Progenitor Cells
  • Implantation
  • Metaplasia
  • Pathogenesis
  • Progenitor Cells
  • Regeneration
  • Review
  • Stem

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Immunology and Microbiology


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