Stereospecific analysis of omeprazole in human plasma as a probe for CYP2C19 phenotype

Medicine & Life Sciences

• Cytochrome P-450 CYP2C19 92%
• Omeprazole 85%
• Phenotype 42%
• Cytochrome P-450 CYP3A 15%
• Acids 15%
• Proton Pump Inhibitors 15%
• omeprazole sulfone 13%
• 5-hydroxymethylomeprazole 13%
• ammonium acetate 10%
• Pharmaceutical Preparations 8%
• acetonitrile 8%
• Circular Dichroism 8%
• Liver Microsomes 8%
• Metabolome 7%
• Gastrointestinal Diseases 7%
• Liver 7%
• Isoenzymes 7%
• Cytochrome P-450 Enzyme System 6%
• Buffers 6%
• Phosphates 6%
• Population 5%
• Pharmacokinetics 5%
• Stomach 5%
• Mutation 3%
• Genes 2%
• Therapeutics 2%

Chemical Compounds

• Omeprazole 100%
• Plasma 43%
• Probe 42%
• Proton Pump Inhibitor 19%
• Column Like Crystal 11%
• Drug 10%
• Enantiomer 9%
• Pharmacological Metabolism 9%
• Plasma Concentration 7%
• Ammonium Acetate 6%
• Eluent 6%
• Sulfone 6%
• Cytochrome 5%
• Disorder 5%
• Mutation 5%
• Circular Dichroism 5%
• Metabolic 5%
• Dose 4%
• Pharmacokinetics 4%
• Acetonitrile 4%
• Metabolite 4%
• Compound Isomer 4%
• Phosphate 4%
• Buffer Solution 4%
• Acid 2%