Stimulus-induced seizure in sick neonates - Novel observations with potential clinical implications

Toshiki Takenouchi, Vivien L. Yap, Murray Engel, Jeffrey M. Perlman

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Stimulus-induced seizure is a well-described entity in children and adults and is often associated with severe epilepsy and neurologic impairment. The occurrence and clinical expression of stimulus-induced seizure in three sick neonates is described. The cohort comprised 26 neonates undergoing continuous video-electroencephalography (vEEG) monitoring between July and December 2007. Three cases (11.5%) of stimulus-induced seizure were identified. The underlying injury included stroke (n = 2) and intraventricular hemorrhage (n = 1). Seizures were induced by physical stimuli such as stroking the forehead, movements, (i.e., starting to feed), and one during endotracheal suctioning. Stimulus-evoked electrographic patterns have been reported in neonates with brain injury; however, these events appear to be more common than previously thought, especially with the abundance of subclinical seizures observed in these patients. These observations stress the usefulness of vEEG monitoring and importance of care to avoid unnecessary stimuli in at-risk neonates.

Original languageEnglish
Pages (from-to)308-311
Number of pages4
Issue number2
Publication statusPublished - 2010
Externally publishedYes


  • Neonates
  • Stimulus-induced seizures
  • Video-electroencephalography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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