TY - JOUR
T1 - Strategic approaches to regeneration of a damaged central nervous system
AU - Okano, Hideyuki
PY - 2011/10/1
Y1 - 2011/10/1
N2 - It has long been believed that a damaged central nervous system (CNS) is difficult to regenerate; however, as a result of the rapid progress in biomedical science, including stem cell biology, there has been a renewed and an increasing interest in developing regenerative therapies for the CNS. Driving this interest has been the discovery of neural stem cells in the adult mammalian CNS, including the human CNS, and the finding that neurogenesis occurs in the adult brain. To achieve regeneration of a damaged CNS, our main strategies encompass: (1) axonal regeneration, (2) replenishment of lost neural cells, and (3) functional recovery. In this review, achievements using these approaches will be outlined.
AB - It has long been believed that a damaged central nervous system (CNS) is difficult to regenerate; however, as a result of the rapid progress in biomedical science, including stem cell biology, there has been a renewed and an increasing interest in developing regenerative therapies for the CNS. Driving this interest has been the discovery of neural stem cells in the adult mammalian CNS, including the human CNS, and the finding that neurogenesis occurs in the adult brain. To achieve regeneration of a damaged CNS, our main strategies encompass: (1) axonal regeneration, (2) replenishment of lost neural cells, and (3) functional recovery. In this review, achievements using these approaches will be outlined.
KW - induced pluripotent stem cells
KW - neural stem cells
KW - semaphorin 3A
KW - spinal cord injury
UR - http://www.scopus.com/inward/record.url?scp=80052704066&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052704066&partnerID=8YFLogxK
U2 - 10.1097/ICO.0b013e3182281879
DO - 10.1097/ICO.0b013e3182281879
M3 - Article
C2 - 21912223
AN - SCOPUS:80052704066
SN - 0277-3740
VL - 30
SP - S15-S18
JO - Cornea
JF - Cornea
IS - 10 SUPPL. 1
ER -