Strategies for therapy of retinal diseases using systemic drug delivery: Relevance of transporters at the bloodretinal barrier

Ken Ichi Hosoya, Masatoshi Tomi, Masanori Tachikawa

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)


Introduction: There is an increasing need for managing rapidly progressing retinal diseases because of the potential loss of vision. Although systemic drug administration is one possible route for treating retinal diseases, retinal transfer of therapeutic drugs from the circulating blood is strictly regulated by the bloodretinal barrier (BRB). Areas covered: This review discusses the constraints and challenges of drug delivery to the retina. In addition, this article discusses the properties of drugs and the conditions of the BRB that affect drug permeability. The reader will gain insights into the strategies for developing therapeutic drugs that are able to cross the BRB for treating retinal diseases. Further, the reader will gain insights into the role of BRB physiology including barrier functions, and the effect of influx and efflux transporters on retinal drug delivery. Expert opinion: When designing and selecting optimal drug candidates, it's important to consider the fact that they should be recognized by influx transporters and that efflux transporters at the BRB should be avoided. Although lipophilic cationic drugs are known to be transported to the brain across the bloodbrain barrier, verapamil transport to the retina is substantially higher than to the brain. Therefore, lipophilic cationic drugs do have a great ability to increase influx transport across the BRB.

Original languageEnglish
Pages (from-to)1571-1587
Number of pages17
JournalExpert Opinion on Drug Delivery
Issue number12
Publication statusPublished - 2011 Dec


  • ABC transporters
  • Drug delivery
  • Inner bloodretinal barrier
  • Outer bloodretinal barrier
  • Retina
  • SLC transporters

ASJC Scopus subject areas

  • Pharmaceutical Science


Dive into the research topics of 'Strategies for therapy of retinal diseases using systemic drug delivery: Relevance of transporters at the bloodretinal barrier'. Together they form a unique fingerprint.

Cite this