TY - JOUR
T1 - Striatal Dopaminergic Depletion Pattern Reflects Pathological Brain Perfusion Changes in Lewy Body Diseases
AU - Iwabuchi, Yu
AU - Shiga, Tohru
AU - Kameyama, Masashi
AU - Miyazawa, Raita
AU - Seki, Morinobu
AU - Ito, Daisuke
AU - Uchida, Hiroyuki
AU - Tabuchi, Hajime
AU - Jinzaki, Masahiro
N1 - Funding Information:
MJ received research grants from Nihon Medi-Physics Co., Ltd. and GE Healthcare Corp. MK received a research grant from Nihon Medi-Physics Co., Ltd. Other authors declare no conflict of interest.
Funding Information:
This work was supported by JSPS KAKENHI (Grant Number: JP19K17243).
Funding Information:
The authors thank the staff of the Division of Nuclear Medicine at the Department of Radiology for their valuable support.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Purpose: In Lewy body diseases (LBD), various symptoms occur depending on the distribution of Lewy body in the brain, and the findings of brain perfusion and dopamine transporter single-photon emission computed tomography (DAT-SPECT) also change accordingly. We aimed to evaluate the correlation between brain perfusion SPECT and quantitative indices calculated from DAT-SPECT in patients with LBD. Procedures: We retrospectively enrolled 35 patients with LBD who underwent brain perfusion SPECT with N-isopropyl-p-[123I] iodoamphetamine and DAT-SPECT with 123I-ioflupane. Mini-mental state examination (MMSE) data were also collected from 19 patients. Quantitative indices (specific binding ratio [SBR], putamen-to-caudate ratio [PCR], and caudate-to-putamen ratio [CPR]) were calculated using DAT-SPECT. These data were analysed by the statistical parametric mapping procedure. Results: In patients with LBD, decreased PCR index correlated with hypoperfusion in the brainstem (medulla oblongata and midbrain) (uncorrected p < 0.001, k > 100), while decreased CPR index correlated with hypoperfusion in the right temporoparietal cortex (family-wise error corrected p < 0.05), right precuneus (uncorrected p < 0.001, k > 100), and bilateral temporal cortex (uncorrected p < 0.001, k > 100). However, there was no significant correlation between decreased SBR index and brain perfusion. Additionally, the MMSE score was correlated with hypoperfusion in the left temporoparietal cortex (uncorrected p < 0.001). Conclusions: This study suggests that regional changes in striatal 123I-ioflupane accumulation on DAT-SPECT are related to brain perfusion changes in patients with LBD.
AB - Purpose: In Lewy body diseases (LBD), various symptoms occur depending on the distribution of Lewy body in the brain, and the findings of brain perfusion and dopamine transporter single-photon emission computed tomography (DAT-SPECT) also change accordingly. We aimed to evaluate the correlation between brain perfusion SPECT and quantitative indices calculated from DAT-SPECT in patients with LBD. Procedures: We retrospectively enrolled 35 patients with LBD who underwent brain perfusion SPECT with N-isopropyl-p-[123I] iodoamphetamine and DAT-SPECT with 123I-ioflupane. Mini-mental state examination (MMSE) data were also collected from 19 patients. Quantitative indices (specific binding ratio [SBR], putamen-to-caudate ratio [PCR], and caudate-to-putamen ratio [CPR]) were calculated using DAT-SPECT. These data were analysed by the statistical parametric mapping procedure. Results: In patients with LBD, decreased PCR index correlated with hypoperfusion in the brainstem (medulla oblongata and midbrain) (uncorrected p < 0.001, k > 100), while decreased CPR index correlated with hypoperfusion in the right temporoparietal cortex (family-wise error corrected p < 0.05), right precuneus (uncorrected p < 0.001, k > 100), and bilateral temporal cortex (uncorrected p < 0.001, k > 100). However, there was no significant correlation between decreased SBR index and brain perfusion. Additionally, the MMSE score was correlated with hypoperfusion in the left temporoparietal cortex (uncorrected p < 0.001). Conclusions: This study suggests that regional changes in striatal 123I-ioflupane accumulation on DAT-SPECT are related to brain perfusion changes in patients with LBD.
KW - I-FP-CIT
KW - Parkinsonian syndrome
KW - Parkinsonism
KW - SPM
KW - α-synuclein
KW - α-synucleinopathy
UR - http://www.scopus.com/inward/record.url?scp=85131819847&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85131819847&partnerID=8YFLogxK
U2 - 10.1007/s11307-022-01745-x
DO - 10.1007/s11307-022-01745-x
M3 - Article
C2 - 35701723
AN - SCOPUS:85131819847
SN - 1536-1632
VL - 24
SP - 950
EP - 958
JO - Molecular Imaging and Biology
JF - Molecular Imaging and Biology
IS - 6
ER -
