TY - JOUR
T1 - Stromal metalloproteinases
T2 - Crucial contributors to the tumor microenvironment
AU - Shimoda, Masayuki
AU - Ohtsuka, Takashi
AU - Okada, Yasunori
AU - Kanai, Yae
N1 - Funding Information:
M.S. was supported by JSPS KAKENHI Grant 16K08719, Research Grant of the Princess Takamatsu Cancer Research Fund and grants from the Takeda Science Foundation, the Public Trust Fund for Clinical Cancer Research, SGH foundation, Suzuken Memorial Foundation and Cancer Research Institute of Kanazawa University. Masayuki Shimoda has been announced as the winner of The Japanese Society of Pathology; Pathology Research Award in 2017.
Funding Information:
M.S. was supported by JSPS KAKENHI Grant 16K08719, Research Grant of the Princess Takamatsu Cancer Research Fund and grants from the Takeda Science Foundation, the Public Trust Fund for Clinical Cancer Research, SGH foundation, Suzuken Memorial Foundation and Cancer Research Institute of Kanazawa University. Masayuki Shimoda has been announced as the winner of The Japanese Society of Pathology; Pathology Research Award in 2017.
Publisher Copyright:
© 2020 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd
PY - 2021/1
Y1 - 2021/1
N2 - Proteolytic balance is crucial for the maintenance of tissue homeostasis. In cancer, dysregulated proteolysis is involved in unregulated tissue remodeling and inflammation, leading to the promotion of tumor growth, local invasion, and metastasis. Metalloproteinases, which were first identified as collagen cleaving enzymes, have been shown to extensively degrade extracellular matrix proteins or selectively release cell surface-bound cytokines, growth factors, or their receptors, thereby impacting extracellular matrix integrity, immune cell recruitment and tissue turnover. Although tumor cells produce various metalloproteinases, the major source is thought to be stromal cells infiltrating the tumor. Different types of stromal cells express specific sets of metalloproteinases and their inhibitors, which specifically alter the milieu within the tumor. In this review, recent findings and knowledge regarding metalloproteinases derived from stromal cells during the creation of the tumor microenvironment are described and their contribution to the tumor progression and metastasis discussed.
AB - Proteolytic balance is crucial for the maintenance of tissue homeostasis. In cancer, dysregulated proteolysis is involved in unregulated tissue remodeling and inflammation, leading to the promotion of tumor growth, local invasion, and metastasis. Metalloproteinases, which were first identified as collagen cleaving enzymes, have been shown to extensively degrade extracellular matrix proteins or selectively release cell surface-bound cytokines, growth factors, or their receptors, thereby impacting extracellular matrix integrity, immune cell recruitment and tissue turnover. Although tumor cells produce various metalloproteinases, the major source is thought to be stromal cells infiltrating the tumor. Different types of stromal cells express specific sets of metalloproteinases and their inhibitors, which specifically alter the milieu within the tumor. In this review, recent findings and knowledge regarding metalloproteinases derived from stromal cells during the creation of the tumor microenvironment are described and their contribution to the tumor progression and metastasis discussed.
KW - a disintegrin and metalloproteinase
KW - cancer-associated fibroblast
KW - extracellular matrix
KW - extracellular vesicle
KW - matrix metalloproteinase
KW - metalloproteinase
KW - tumor microenvironment
KW - tumor-associated macrophage
UR - http://www.scopus.com/inward/record.url?scp=85092661196&partnerID=8YFLogxK
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U2 - 10.1111/pin.13033
DO - 10.1111/pin.13033
M3 - Review article
C2 - 33074556
AN - SCOPUS:85092661196
SN - 1320-5463
VL - 71
SP - 1
EP - 14
JO - Pathology international
JF - Pathology international
IS - 1
ER -
