Structure-activity relationship of okadaic acid, a potent protein phosphatases PP1 and PP2A inhibitor: 24-epi-okadaic acid and a 18-membered lactone analog

Masaki Kita; Makoto Kuramoto; Tatsuhiko Chiba; Akihiro Yamada; Nobuko Yamada; Takako Ishida; Takeharu Haino; Kaoru Yamada; Yasuharu Ijuin; Osamu Ohno; Daisuke Uemura

doi:10.3987/COM-08-S(N)88

Structure-activity relationship of okadaic acid, a potent protein phosphatases PP1 and PP2A inhibitor: 24-epi-okadaic acid and a 18-membered lactone analog

Masaki Kita, Makoto Kuramoto, Tatsuhiko Chiba, Akihiro Yamada, Nobuko Yamada, Takako Ishida, Takeharu Haino, Kaoru Yamada, Yasuharu Ijuin, Osamu Ohno, Daisuke Uemura

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

X-Ray crystallographic analysis and structure-activity relationship of okadaic acid revealed that the flexible cavity structure stabilized by intramolecular hydrogen bonds is important for its potent cytotoxicity.

Original language	English
Pages (from-to)	1033-1042
Number of pages	10
Journal	Heterocycles
Volume	76
Issue number	2
DOIs	https://doi.org/10.3987/COM-08-S(N)88
Publication status	Published - 2008 Nov 1
Externally published	Yes

Keywords

24-epi-OA
Flexible Cavity Structure
OA Lactone
Ocadaic Acid
Protein Phosphatase

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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10.3987/COM-08-S(N)88

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title = "Structure-activity relationship of okadaic acid, a potent protein phosphatases PP1 and PP2A inhibitor: 24-epi-okadaic acid and a 18-membered lactone analog",

abstract = "X-Ray crystallographic analysis and structure-activity relationship of okadaic acid revealed that the flexible cavity structure stabilized by intramolecular hydrogen bonds is important for its potent cytotoxicity.",

keywords = "24-epi-OA, Flexible Cavity Structure, OA Lactone, Ocadaic Acid, Protein Phosphatase",

author = "Masaki Kita and Makoto Kuramoto and Tatsuhiko Chiba and Akihiro Yamada and Nobuko Yamada and Takako Ishida and Takeharu Haino and Kaoru Yamada and Yasuharu Ijuin and Osamu Ohno and Daisuke Uemura",

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doi = "10.3987/COM-08-S(N)88",

language = "English",

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T1 - Structure-activity relationship of okadaic acid, a potent protein phosphatases PP1 and PP2A inhibitor

T2 - 24-epi-okadaic acid and a 18-membered lactone analog

AU - Kita, Masaki

AU - Kuramoto, Makoto

AU - Chiba, Tatsuhiko

AU - Yamada, Akihiro

AU - Yamada, Nobuko

AU - Ishida, Takako

AU - Haino, Takeharu

AU - Yamada, Kaoru

AU - Ijuin, Yasuharu

AU - Ohno, Osamu

AU - Uemura, Daisuke

PY - 2008/11/1

Y1 - 2008/11/1

N2 - X-Ray crystallographic analysis and structure-activity relationship of okadaic acid revealed that the flexible cavity structure stabilized by intramolecular hydrogen bonds is important for its potent cytotoxicity.

AB - X-Ray crystallographic analysis and structure-activity relationship of okadaic acid revealed that the flexible cavity structure stabilized by intramolecular hydrogen bonds is important for its potent cytotoxicity.

KW - 24-epi-OA

KW - Flexible Cavity Structure

KW - OA Lactone

KW - Ocadaic Acid

KW - Protein Phosphatase

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DO - 10.3987/COM-08-S(N)88

M3 - Article

AN - SCOPUS:61349096715

SN - 0385-5414

VL - 76

SP - 1033

EP - 1042

JO - Heterocycles

JF - Heterocycles

IS - 2

ER -

Structure-activity relationship of okadaic acid, a potent protein phosphatases PP1 and PP2A inhibitor: 24-epi-okadaic acid and a 18-membered lactone analog

Abstract

Keywords

ASJC Scopus subject areas

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