Structures and functions of the gut microbial lipidome

Satoshi Morozumi; Masahiro Ueda; Nobuyuki Okahashi; Makoto Arita

doi:10.1016/j.bbalip.2021.159110

Structures and functions of the gut microbial lipidome

Satoshi Morozumi, Masahiro Ueda, Nobuyuki Okahashi, Makoto Arita

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.

Original language	English
Article number	159110
Journal	Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume	1867
Issue number	3
DOIs	https://doi.org/10.1016/j.bbalip.2021.159110
Publication status	Published - 2022 Mar

Keywords

Bioactive lipids
Lipidomics
Microbiome

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.bbalip.2021.159110

Cite this

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title = "Structures and functions of the gut microbial lipidome",

abstract = "Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.",

keywords = "Bioactive lipids, Lipidomics, Microbiome",

author = "Satoshi Morozumi and Masahiro Ueda and Nobuyuki Okahashi and Makoto Arita",

note = "Funding Information: This work was supported by AMED LEAP grant number JP18gm0010003 , JSPS KAKENHI grant numbers 15H05897 , 15H05898 and 20H00495 , AMED grant number JP21ae0121036 , Terumo Life Science Foundation, and JST ERATO grant number JPMJER2101 , Japan. We would like to thank Editage ( www.editage.jp ) for English language editing. Publisher Copyright: {\textcopyright} 2022 The Authors",

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doi = "10.1016/j.bbalip.2021.159110",

language = "English",

volume = "1867",

journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",

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AU - Morozumi, Satoshi

AU - Ueda, Masahiro

AU - Okahashi, Nobuyuki

AU - Arita, Makoto

N1 - Funding Information: This work was supported by AMED LEAP grant number JP18gm0010003 , JSPS KAKENHI grant numbers 15H05897 , 15H05898 and 20H00495 , AMED grant number JP21ae0121036 , Terumo Life Science Foundation, and JST ERATO grant number JPMJER2101 , Japan. We would like to thank Editage ( www.editage.jp ) for English language editing. Publisher Copyright: © 2022 The Authors

PY - 2022/3

Y1 - 2022/3

N2 - Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.

AB - Microbial lipids provide signals that are responsible for maintaining host health and controlling disease. The differences in the structures of microbial lipids have been shown to alter receptor selectivity and agonist/antagonist activity. Advanced lipidomics is an emerging field that helps to elucidate the complex bacterial lipid diversity. The use of cutting-edge technologies is expected to lead to the discovery of new functional metabolites involved in host homeostasis. This review aims to describe recent updates on functional lipid metabolites derived from gut microbiota, their structure-activity relationships, and advanced lipidomics technologies.

KW - Bioactive lipids

KW - Lipidomics

KW - Microbiome

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DO - 10.1016/j.bbalip.2021.159110

M3 - Review article

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AN - SCOPUS:85122467539

SN - 1388-1981

VL - 1867

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

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ER -

Structures and functions of the gut microbial lipidome

Abstract

Keywords

ASJC Scopus subject areas

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