Studies on Crude Drugs Effective on Visceral Larva Migrans. I. Identification of Larvicidal Principles in Betel Nuts

Fumiyuki Kiuchi; Naoshi Miyashita; Yoshisuke Tsuda; Hiroyuki Yoshimura; Kaoru Kondo

doi:10.1248/cpb.35.2880

Studies on Crude Drugs Effective on Visceral Larva Migrans. I. Identification of Larvicidal Principles in Betel Nuts

Fumiyuki Kiuchi, Naoshi Miyashita, Yoshisuke Tsuda, Hiroyuki Yoshimura, Kaoru Kondo

Research output: Contribution to journal › Article › peer-review

77 Citations (Scopus)

Abstract

Larvicidal principles obtained from the 50% aqueous acetone extract of betel nuts (Areca catechu) were revealed to be a mixture of fatty acids. They were identified by GC-MS analysis as lauric, myristic, palmitic, and oleic acids. Determination of the larvicidal activities of fatty acids and aliphatic alcohols with various alkyl chain lengths, and of analogous compounds with various functional groups, suggested that the balance between hydrophilicity and hydrophobicity is important for the larvicidal activity.

Original language	English
Pages (from-to)	2880-2886
Number of pages	7
Journal	Chemical and Pharmaceutical Bulletin
Volume	35
Issue number	7
DOIs	https://doi.org/10.1248/cpb.35.2880
Publication status	Published - 1987
Externally published	Yes

Keywords

Areca catechu
Toxocara canis
aliphatic alcohol
anthelmintic
betel chewing
fatty acid
larva
larvicide
tannin

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.35.2880

Cite this

@article{ed08adeba91941e5affbdd589557c637,

title = "Studies on Crude Drugs Effective on Visceral Larva Migrans. I. Identification of Larvicidal Principles in Betel Nuts",

abstract = "Larvicidal principles obtained from the 50% aqueous acetone extract of betel nuts (Areca catechu) were revealed to be a mixture of fatty acids. They were identified by GC-MS analysis as lauric, myristic, palmitic, and oleic acids. Determination of the larvicidal activities of fatty acids and aliphatic alcohols with various alkyl chain lengths, and of analogous compounds with various functional groups, suggested that the balance between hydrophilicity and hydrophobicity is important for the larvicidal activity.",

keywords = "Areca catechu, Toxocara canis, aliphatic alcohol, anthelmintic, betel chewing, fatty acid, larva, larvicide, tannin",

author = "Fumiyuki Kiuchi and Naoshi Miyashita and Yoshisuke Tsuda and Hiroyuki Yoshimura and Kaoru Kondo",

year = "1987",

doi = "10.1248/cpb.35.2880",

language = "English",

volume = "35",

pages = "2880--2886",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "7",

}

TY - JOUR

T1 - Studies on Crude Drugs Effective on Visceral Larva Migrans. I. Identification of Larvicidal Principles in Betel Nuts

AU - Kiuchi, Fumiyuki

AU - Miyashita, Naoshi

AU - Tsuda, Yoshisuke

AU - Yoshimura, Hiroyuki

AU - Kondo, Kaoru

PY - 1987

Y1 - 1987

N2 - Larvicidal principles obtained from the 50% aqueous acetone extract of betel nuts (Areca catechu) were revealed to be a mixture of fatty acids. They were identified by GC-MS analysis as lauric, myristic, palmitic, and oleic acids. Determination of the larvicidal activities of fatty acids and aliphatic alcohols with various alkyl chain lengths, and of analogous compounds with various functional groups, suggested that the balance between hydrophilicity and hydrophobicity is important for the larvicidal activity.

AB - Larvicidal principles obtained from the 50% aqueous acetone extract of betel nuts (Areca catechu) were revealed to be a mixture of fatty acids. They were identified by GC-MS analysis as lauric, myristic, palmitic, and oleic acids. Determination of the larvicidal activities of fatty acids and aliphatic alcohols with various alkyl chain lengths, and of analogous compounds with various functional groups, suggested that the balance between hydrophilicity and hydrophobicity is important for the larvicidal activity.

KW - Areca catechu

KW - Toxocara canis

KW - aliphatic alcohol

KW - anthelmintic

KW - betel chewing

KW - fatty acid

KW - larva

KW - larvicide

KW - tannin

UR - http://www.scopus.com/inward/record.url?scp=0023188929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023188929&partnerID=8YFLogxK

U2 - 10.1248/cpb.35.2880

DO - 10.1248/cpb.35.2880

M3 - Article

C2 - 3677238

AN - SCOPUS:0023188929

SN - 0009-2363

VL - 35

SP - 2880

EP - 2886

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 7

ER -

Studies on Crude Drugs Effective on Visceral Larva Migrans. I. Identification of Larvicidal Principles in Betel Nuts

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this