Study of drug delivery to vascular wall with a heating ex vivo

Machiko Shinozuka, Natsumi Shimazaki, Tsunenori Arai

Research output: Contribution to journalArticlepeer-review


We studied the drug delivery methodology on a vascular wall with a heating to improve drug delivery performance. The drug delivery has been used for hyperplasia suppression such as the drug eluting stent. We think thermal denature of vascular collagen might lengthen drug penetration depth to the media because of collagen structure change. The drug concentration and penetration depth in vascular were measured by a fluorescent microscope after 15 s of immersing vascular pieces in heated 3.5 μg/ml Rhodamine B solution. The heating temperature was set to 50-70 and 37°C for control. The drug concentration and penetration depth increased with heating temperature increasing. The drug concentration was 10-10<sup>4</sup> times higher than the control. The penetration depth was 2-9 times longer than the control. We found possibility of drug delivery performance improvement by the means of thermal denatured collagen in the vascular wall.

Original languageEnglish
Pages (from-to)O-72
JournalTransactions of Japanese Society for Medical and Biological Engineering
Publication statusPublished - 2014 Aug 17


  • Collagen
  • Drug delivery
  • Heating
  • Vascular

ASJC Scopus subject areas

  • Biomedical Engineering


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