Abstract
Anti-DNA antibody synthesis by lymphocytes from normal individuals and systemic lupus erythematosus (SLE) patients was investigated. Anti-DNA antibody synthesis in response to DNA was demonstrated in SLE, but not in normal individuals. DNA was T cell-dependent antigen in anti-DNA antibody synthesis. Anti-DNA antibody synthesis by SLE lymphocytes was suppressed by T8 cells and enhanced by T4 cells in inactive stage. However, in active stage, SLE T8 cells failed to suppress anti-DNA antibody synthesis, even in any T4/T8 ratio. These results indicated that DNA-specific suppressor T cell dysfunction was in part responsible for the elevated anti-DNA antibody synthesis in SLE lymphocytes in response to DNA.
| Original language | English |
|---|---|
| Pages (from-to) | 555-560 |
| Number of pages | 6 |
| Journal | Japanese Journal of Clinical Immunology |
| Volume | 6 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1983 Jan |
Keywords
- DNA
- SLE
- T cells
- T cells
- anti-DNA antibody
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology