Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms

Hikaru Takeuchi; Yasuyuki Taki; Rui Nouchi; Ryoichi Yokoyama; Yuka Kotozaki; Seishu Nakagawa; Atsushi Sekiguchi; Kunio Iizuka; Sugiko Hanawa; Tsuyoshi Araki; Carlos Makoto Miyauchi; Kohei Sakaki; Takayuki Nozawa; Shigeyuki Ikeda; Susum Yokota; Daniele Magistro; Yuko Sassa; Ryuta Kawashima

doi:10.1038/s41598-020-69277-4

Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms

Hikaru Takeuchi, Yasuyuki Taki, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka, Sugiko Hanawa, Tsuyoshi Araki, Carlos Makoto Miyauchi, Kohei Sakaki, Takayuki Nozawa, Shigeyuki Ikeda, Susum Yokota, Daniele Magistro, Yuko Sassa, Ryuta Kawashima

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Zinc is a biologically essential element and involved in a wide range of cellular processes. Here, we investigated the associations of zinc levels in hair with brain activity during the n-back working memory task using functional magnetic resonance imaging, fractional anisotropy (FA) of diffusion tensor imaging, and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that greater hair zinc levels were associated with lower brain activity during working memory in extensive areas in the default mode network (i.e., greater task-induced deactivation) as well as greater FA in white matter areas near the hippocampus and posterior limbs of the internal capsule. These findings advance previous non-neuroimaging findings of zinc’s associations with excitability, excitability-associated disorders, and myelination.

Original language	English
Article number	12364
Journal	Scientific reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-69277-4
Publication status	Published - 2020 Dec 1
Externally published	Yes

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Takeuchi, H., Taki, Y., Nouchi, R., Yokoyama, R., Kotozaki, Y., Nakagawa, S., Sekiguchi, A., Iizuka, K., Hanawa, S., Araki, T., Miyauchi, C. M., Sakaki, K., Nozawa, T., Ikeda, S., Yokota, S., Magistro, D., Sassa, Y., & Kawashima, R. (2020). Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms. Scientific reports, 10(1), Article 12364. https://doi.org/10.1038/s41598-020-69277-4

Takeuchi, H, Taki, Y, Nouchi, R, Yokoyama, R, Kotozaki, Y, Nakagawa, S, Sekiguchi, A, Iizuka, K, Hanawa, S, Araki, T, Miyauchi, CM, Sakaki, K, Nozawa, T, Ikeda, S, Yokota, S, Magistro, D, Sassa, Y & Kawashima, R 2020, 'Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms', Scientific reports, vol. 10, no. 1, 12364. https://doi.org/10.1038/s41598-020-69277-4

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title = "Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms",

abstract = "Zinc is a biologically essential element and involved in a wide range of cellular processes. Here, we investigated the associations of zinc levels in hair with brain activity during the n-back working memory task using functional magnetic resonance imaging, fractional anisotropy (FA) of diffusion tensor imaging, and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that greater hair zinc levels were associated with lower brain activity during working memory in extensive areas in the default mode network (i.e., greater task-induced deactivation) as well as greater FA in white matter areas near the hippocampus and posterior limbs of the internal capsule. These findings advance previous non-neuroimaging findings of zinc{\textquoteright}s associations with excitability, excitability-associated disorders, and myelination.",

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doi = "10.1038/s41598-020-69277-4",

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AU - Takeuchi, Hikaru

AU - Taki, Yasuyuki

AU - Nouchi, Rui

AU - Yokoyama, Ryoichi

AU - Kotozaki, Yuka

AU - Nakagawa, Seishu

AU - Sekiguchi, Atsushi

AU - Iizuka, Kunio

AU - Hanawa, Sugiko

AU - Araki, Tsuyoshi

AU - Miyauchi, Carlos Makoto

AU - Sakaki, Kohei

AU - Nozawa, Takayuki

AU - Ikeda, Shigeyuki

AU - Yokota, Susum

AU - Magistro, Daniele

AU - Sassa, Yuko

AU - Kawashima, Ryuta

PY - 2020/12/1

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AB - Zinc is a biologically essential element and involved in a wide range of cellular processes. Here, we investigated the associations of zinc levels in hair with brain activity during the n-back working memory task using functional magnetic resonance imaging, fractional anisotropy (FA) of diffusion tensor imaging, and cognitive differences in a study cohort of 924 healthy young adults. Our findings showed that greater hair zinc levels were associated with lower brain activity during working memory in extensive areas in the default mode network (i.e., greater task-induced deactivation) as well as greater FA in white matter areas near the hippocampus and posterior limbs of the internal capsule. These findings advance previous non-neuroimaging findings of zinc’s associations with excitability, excitability-associated disorders, and myelination.

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Succeeding in deactivating: associations of hair zinc levels with functional and structural neural mechanisms

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