Successful pregnancy and normal delivery after whole craniospinal irradiation in two patients

Naoyuki Shigematsu, Hiroshi Shinmoto, Nobutake Ito, Etsuo Kunieda, Atsuya Takeda, Toshio Ohashi, Osamu Kawaguchi, Tetsuya Kawata, Hisao Ito, Sachio Kuribayashi, Atsushi Kubo

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Two cases of normal pregnancies and deliveries after whole craniospinal irradiation (WCSI) are described, and whether the ovaries can be left out of the WCSI field by identifying ovarian position using magnetic resonance imaging (MRI) is determined. Materials and Methods: The distance between the upper edge of the pubic symphysis and the central part of the ovary was measured on MRI in 17 women. Results: The right ovary was located 20.3-68.4 mm to the right of and 33.7-113.5 mm above the upper edge of the pubic symphysis; the left ovary was located 26.2-72.5 mm to the left and 25.8-106.6 mm above this edge. The lower border of the spinal field in WCSI should be the caudal border of the thecal sac, i.e., S2-S4. The line of this location, which nearly approximates normal ovarian position, should be employed in radiotherapy planning to avoid irradiating at least one ovary with its thecal sac. Omitting this area from the WCSI field in women of childbearing age with a good long-term prognosis, preserves potential fertility. Conclusion: It appears that the ovaries might be excluded from the WCSI field, using appropriate techniques, so as to preserve female fertility.

Original languageEnglish
Pages (from-to)3481-3487
Number of pages7
JournalAnticancer research
Issue number5
Publication statusPublished - 2005 Sept


  • Craniospinal irradiation
  • Fertility
  • MR
  • Ovarian position

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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