Successful Treatment for Hypercalcemia due to Cosecretion of Parathyroid Hormone-Related Protein and 1,25-Dihydroxyvitamin D3in Non-Small-Cell Lung Cancer: A Case Report and Literature Review

Takunori Ogawa; Jun Miyata; Koichi Fukunaga; Akihiko Kawana; Takashi Inoue

doi:10.1155/2020/2475725

Successful Treatment for Hypercalcemia due to Cosecretion of Parathyroid Hormone-Related Protein and 1,25-Dihydroxyvitamin D₃in Non-Small-Cell Lung Cancer: A Case Report and Literature Review

Takunori Ogawa, Jun Miyata, Koichi Fukunaga, Akihiko Kawana, Takashi Inoue

Department of Internal Medicine (Pulmonary Medicine)

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Hypercalcemia of malignancy frequently manifests as paraneoplastic syndrome in patients with solid tumors. A 71-year-old man was diagnosed with stage IIIB lung squamous cell carcinoma. Laboratory examination revealed high serum calcium concentration with elevated serum parathyroid hormone-related protein (PTHrP) and 1,25-dihydroxyvitamin D3 levels. As the patient did not respond to the initial treatment with calcitonin, extracellular fluid infusion, and chemotherapy, systemic prednisolone was administered additionally. Thus, the levels of serum calcium normalized and PTHrP and 1,25-dihydroxyvitamin D3 decreased simultaneously. To our knowledge, this is the first case report on the successful treatment of hypercalcemia of malignancy caused by PTHrP and 1,25-dihydroxyvitamin D3 cosecretion in a patient with lung cancer.

Original language	English
Article number	2475725
Journal	Case Reports in Pulmonology
Volume	2020
DOIs	https://doi.org/10.1155/2020/2475725
Publication status	Published - 2020

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1155/2020/2475725

Cite this

Successful Treatment for Hypercalcemia due to Cosecretion of Parathyroid Hormone-Related Protein and 1,25-Dihydroxyvitamin D₃in Non-Small-Cell Lung Cancer: A Case Report and Literature Review. / Ogawa, Takunori; Miyata, Jun ; Fukunaga, Koichi et al.
In: Case Reports in Pulmonology, Vol. 2020, 2475725, 2020.

Research output: Contribution to journal › Article › peer-review

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abstract = "Hypercalcemia of malignancy frequently manifests as paraneoplastic syndrome in patients with solid tumors. A 71-year-old man was diagnosed with stage IIIB lung squamous cell carcinoma. Laboratory examination revealed high serum calcium concentration with elevated serum parathyroid hormone-related protein (PTHrP) and 1,25-dihydroxyvitamin D3 levels. As the patient did not respond to the initial treatment with calcitonin, extracellular fluid infusion, and chemotherapy, systemic prednisolone was administered additionally. Thus, the levels of serum calcium normalized and PTHrP and 1,25-dihydroxyvitamin D3 decreased simultaneously. To our knowledge, this is the first case report on the successful treatment of hypercalcemia of malignancy caused by PTHrP and 1,25-dihydroxyvitamin D3 cosecretion in a patient with lung cancer.",

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