Successful Treatment of End-stage Renal Disease in a Patient With Chronic Myeloid Leukemia by Kidney Transplantation and Tyrosine Kinase Inhibitors: A Case Report

Kazunobu Shinoda; Shinya Morita; Satoshi Tamaki; Ryohei Takahashi; Sotaro Kitaoka; Hiroshi Asanuma; Tadashi Yoshida; Mikio Okayama; Hidenori Kasahara; Shinichiro Okamoto; Mototsugu Oya

doi:10.1016/j.transproceed.2019.10.035

Successful Treatment of End-stage Renal Disease in a Patient With Chronic Myeloid Leukemia by Kidney Transplantation and Tyrosine Kinase Inhibitors: A Case Report

Kazunobu Shinoda, Shinya Morita, Satoshi Tamaki, Ryohei Takahashi, Sotaro Kitaoka, Hiroshi Asanuma, Tadashi Yoshida, Mikio Okayama, Hidenori Kasahara, Shinichiro Okamoto, Mototsugu Oya

Research output: Contribution to journal › Article › peer-review

Abstract

Consensus regarding kidney transplantation feasibility in patients with chronic myeloid leukemia (CML) well controlled by tyrosine kinase inhibitors has not yet been achieved. Here, we report a patient with CML well controlled by tyrosine kinase inhibitors who developed end-stage renal disease during treatment and underwent kidney transplantation. CML activity has been carefully and successfully controlled for 4 years post-transplant. Very cautious dose adjustment and temporary cessation of nilotinib were required because kidney function fluctuated in reference to the doses of nilotinib.

Original language	English
Pages (from-to)	604-607
Number of pages	4
Journal	Transplantation Proceedings
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/j.transproceed.2019.10.035
Publication status	Published - 2020 Mar

ASJC Scopus subject areas

Surgery
Transplantation

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Shinoda, K., Morita, S., Tamaki, S., Takahashi, R., Kitaoka, S., Asanuma, H., Yoshida, T., Okayama, M., Kasahara, H., Okamoto, S., & Oya, M. (2020). Successful Treatment of End-stage Renal Disease in a Patient With Chronic Myeloid Leukemia by Kidney Transplantation and Tyrosine Kinase Inhibitors: A Case Report. Transplantation Proceedings, 52(2), 604-607. https://doi.org/10.1016/j.transproceed.2019.10.035

Shinoda, K, Morita, S, Tamaki, S, Takahashi, R, Kitaoka, S, Asanuma, H , Yoshida, T, Okayama, M, Kasahara, H, Okamoto, S & Oya, M 2020, 'Successful Treatment of End-stage Renal Disease in a Patient With Chronic Myeloid Leukemia by Kidney Transplantation and Tyrosine Kinase Inhibitors: A Case Report', Transplantation Proceedings, vol. 52, no. 2, pp. 604-607. https://doi.org/10.1016/j.transproceed.2019.10.035

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abstract = "Consensus regarding kidney transplantation feasibility in patients with chronic myeloid leukemia (CML) well controlled by tyrosine kinase inhibitors has not yet been achieved. Here, we report a patient with CML well controlled by tyrosine kinase inhibitors who developed end-stage renal disease during treatment and underwent kidney transplantation. CML activity has been carefully and successfully controlled for 4 years post-transplant. Very cautious dose adjustment and temporary cessation of nilotinib were required because kidney function fluctuated in reference to the doses of nilotinib.",

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doi = "10.1016/j.transproceed.2019.10.035",

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AU - Shinoda, Kazunobu

AU - Morita, Shinya

AU - Tamaki, Satoshi

AU - Takahashi, Ryohei

AU - Kitaoka, Sotaro

AU - Asanuma, Hiroshi

AU - Yoshida, Tadashi

AU - Okayama, Mikio

AU - Kasahara, Hidenori

AU - Okamoto, Shinichiro

AU - Oya, Mototsugu

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AB - Consensus regarding kidney transplantation feasibility in patients with chronic myeloid leukemia (CML) well controlled by tyrosine kinase inhibitors has not yet been achieved. Here, we report a patient with CML well controlled by tyrosine kinase inhibitors who developed end-stage renal disease during treatment and underwent kidney transplantation. CML activity has been carefully and successfully controlled for 4 years post-transplant. Very cautious dose adjustment and temporary cessation of nilotinib were required because kidney function fluctuated in reference to the doses of nilotinib.

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Successful Treatment of End-stage Renal Disease in a Patient With Chronic Myeloid Leukemia by Kidney Transplantation and Tyrosine Kinase Inhibitors: A Case Report

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