Successful treatment of tafro syndrome with tocilizumab, prednisone, and cyclophosphamide

Taku Kikuchi, Takayuki Shimizu, Takaaki Toyama, Ryohei Abe, Shinichiro Okamoto

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


TAFRO syndrome is a rare systemic inflammatory disease characterized by thrombocytopenia, pleural effusion, fever, renal dysfunction, reticulin fibrosis of the bone marrow, and organomegaly. The clinical course varies significantly among patients. However, the prognosis is usually dismal in patients with severe TAFRO syndrome, and no optimal treatment has yet been established. We herein describe the first case of TAFRO syndrome, which was successfully treated with combination therapy consisting of tocilizumab, prednisone, and cyclophosphamide.

Original languageEnglish
Pages (from-to)2205-2211
Number of pages7
JournalInternal Medicine
Issue number16
Publication statusPublished - 2017


  • Cyclophosphamide
  • TAFRO syndrome
  • Tocilizumab

ASJC Scopus subject areas

  • Internal Medicine


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