TY - JOUR
T1 - Superoxide radical initiates the autoxidation of dihydroxyacetone
AU - Mashino, Tadahiko
AU - Fridovich, Irwin
N1 - Funding Information:
1 This work was supported by research grants from the United States Army Research Office, the Council for Tobacco Research, U.S.A., Inc., and the National Science Foundation. ’ To whom correspondence should be addressed. ’ Abbreviations used: DTPA, diethylenetriaminepentaacetate; DHA, dihydroxyacetone; Cu,ZnSOD, the copper-and zinc-containing superoxide fiismutase; SOD, superoxide dismutase; Desferal, desferrioxamine; DHAP, dihydroxyacetonephosphate.
PY - 1987/5/1
Y1 - 1987/5/1
N2 - The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.
AB - The aerobic xanthine oxidase reaction causes the cooxidation of dihydroxyacetone in a process which is strongly inhibited by superoxide dismutase but not by catalase, HO · scavengers, or iron-inactivating chelating agents. Several molecules of the sugar can be oxidized per O2- introduced. A free radical chain mechanism, in which O2- acts both as an initiator and as a chain propagator, is proposed. Simple sugars capable of tautomerizing to enediols may now be added to the list of biologically relevant targets for O2-.
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U2 - 10.1016/0003-9861(87)90136-6
DO - 10.1016/0003-9861(87)90136-6
M3 - Article
C2 - 3034165
AN - SCOPUS:0023333090
SN - 0003-9861
VL - 254
SP - 547
EP - 551
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
IS - 2
ER -