Surgical repair of post-infarction ventricular septal defect ― findings from a Japanese national database ―

Genichi Sakaguchi, Hiroaki Miyata, Noboru Motomura, Chikara Ueki, Eriko Fukuchi, Hiroyuki Yamamoto, Shinichi Takamoto, Akira Marui

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Background: Ventricular septal defect (VSD) after myocardial infarction (MI) is a rare but fatal complication. We report patients’ characteristics and operative outcomes after surgical repair of post-MI VSD using a national database of Japan. Methods and Results: This was a retrospective review of the Japan Adult Cardiovascular Surgery Database (JCVSD) to identify adults (age ≥18 years) who underwent surgical repair of post-MI VSD between 2008 and 2014. The primary outcome was operative death. We identified 1,397 patients (671 male [48%], 74.1±9.3 years old) undergoing surgical repair of post-MI VSD among 288,736 patients undergoing cardiac surgery enrolled in the JCVSD during the same period. Of these, 1,075 (77.0%) were supported preoperatively with an intra-aortic balloon pump. Surgical status was urgent in 391 (28.0%) and emergency/salvage in 731 (52.3%). Concomitant coronary artery bypass grafting was performed in 475 (34.0%). Overall 30-day and operative mortalities were 24.3% and 33.0%, respectively. Operative mortality varied according to surgical status: 15.6% in elective, 30.9% in urgent, and 40.6% in emergency/salvage cases. Multivariable analysis identified advanced age and emergency/salvage status as being strongly associated with increased odds of operative death. Conclusions: Post-MI VSD remains a devastating complication in Japan as well as in the USA and Europe.

Original languageEnglish
Pages (from-to)2229-2235
Number of pages7
JournalCirculation Journal
Issue number11
Publication statusPublished - 2019


  • Acute myocardial infarction
  • Cardiopulmonary bypass
  • Coronary artery bypass grafts
  • Heart failure
  • Shock

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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